Cytokines, Stress, and Depression

  • Robert Dantzer
  • Emmanuelle E. Wollman
  • Raz Yirmiya

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 461)

Table of contents

  1. Front Matter
    Pages i-x
  2. Depression and Immunity

    1. Michael Irwin
      Pages 1-24
    2. Andreas Seidel, Matthias Rothermundt, Lothar Rink
      Pages 47-57
  3. Brain Effects on Cytokines

    1. Robert Dantzer, Arnaud Aubert, Rose-Marie Bluthé, Gilles Gheusi, Sandrine Cremona, Sophie Layé et al.
      Pages 83-105
    2. Andrew H. Miller, Carmine M. Pariante, Bradley D. Pearce
      Pages 107-116
    3. Adrian J. Dunn, Jianping Wang, Tetsuya Ando
      Pages 117-127
  4. Effects of Stress on Cytokine Production and Actions

    1. Linda R. Watkins, Kien T. Nguyen, Jacqueline E. Lee, Steven F. Maier
      Pages 153-178
    2. J. H. Tilders, E. D. Schmidt
      Pages 179-197
  5. Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression

    1. Hymie Anisman, Zul Merali
      Pages 199-233
    2. Steven F. Maier, Kien T. Nguyen, Terrence Deak, Erin D. Milligan, Linda R. Watkins
      Pages 235-249
    3. B. E. Leonard, Cai Song
      Pages 251-265
  6. Effects of Antidepressants Cytokine Production and Action

    1. Pierre J. Neveu, Nathalie Castanon
      Pages 267-281
    2. Raz Yirmiya, Joseph Weidenfeld, Yehuda Pollak, Michal Morag, Avraham Morag, Ronit Avitsur et al.
      Pages 283-316
    3. Robert Dantzer, Emmanuelle E. Wollman, Ljubisa Vitkovic, Raz Yirmiya
      Pages 317-329
  7. Back Matter
    Pages 331-336

About this book


Cytokines had been characterized in the early eighties as communication mole­ cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.


behavior brain cancer cytokine depression inflammation neuroscience pathophysiology physiology receptor research resistance stress

Editors and affiliations

  • Robert Dantzer
    • 1
  • Emmanuelle E. Wollman
    • 2
  • Raz Yirmiya
    • 3
  1. 1.INRA-INSERMBordeauxFrance
  2. 2.CNRSParisFrance
  3. 3.The Hebrew University of JerusalemJerusalemIsrael

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1999
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-46135-4
  • Online ISBN 978-0-585-37970-8
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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