• W. Evan Secor
  • Daniel G. Colley

Part of the World Class Parasites book series (WCPA, volume 10)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Eric S. Loker, Gerald M. Mkoji
    Pages 1-11
  3. Paul J. Brindley, Claudia S. Copeland, Bernd H. Kalinna
    Pages 13-26
  4. Philip T. LoVerde, Edward G. Niles, Ahmed Osman, Wenjie Wu
    Pages 27-43
  5. David L. Williams, Raymond J. Pierce
    Pages 45-64
  6. Adrian P. Mountford, Stephen J. Jenkins
    Pages 65-79
  7. Thomas Wynn A., Allen Cheever W., Mallika Kaviratne, Robert Thompson W., Margaret Mentink-Kane M., Matthias Hesse
    Pages 125-140
  8. Donald P. McManus, Zheng Feng, Jiagang Guo, Yuesheng Li, Paul B. Bartley, Alex Loukas et al.
    Pages 159-175
  9. Jeffrey M. Bethony, Jeff T. Williams
    Pages 177-190
  10. Donato Cioli, Livia Pica-Mattoccia
    Pages 191-206
  11. Dirk Engels, Lorenzo Savioli
    Pages 207-222
  12. Back Matter
    Pages 233-235

About this book


The goal of Schistosomiasis is to provide the reader with insights into the active research and programs currently related to schistosomiasis, and to use these insights as a way to project forward into the next 10-15 years of work on this disease, spanning the spectrum from research to public health interventions. A secondary goal of this volume is to initiate conversations among those working across the research-to-control spectrum on schistosomiasis about the future of their field, and by doing so lead to constructive efforts to identify and address the most critical questions and challenges related to schistosomiasis. The book covers four main areas: schistosome phylogenetics, gene expression, and the overall genome, including information on exciting new tools for addressing questions that have long been inaccessible to schistosomologists; the host-schistosome interaction at the larval to adult worm interface and addresses aspects important for vaccine development as well as how differential gene expression as detected by DNA microarrays may be utilized to develop tools for detection and control of infection or pathology; the development of the host immune response to eggs, granuloma formation and factors affecting the development and regulation of immunopathology; and the public health concerns associated with schistosomiasis, including morbidity control, host genetics, treatment and proposals for improved partnerships. The volume concludes with a chapter addressing the schisms that sometimes exist along the spectrum from basic research programs to the implementation of control schemes, and a proposal to make these differences benefit patients and researchers rather than succumb to base temptations to compete for resources to no one’s benefit. Like many of the diseases featured in the World Class Parasites series, the prospects for dramatic advances in schistosomiasis coincide with a seemingly shrinking pool of both human and material resources. The most meaningful progress will occur as the laboratory better understands the needs in the field and the field better understands the capabilities of the laboratory.


Schistosomiasis antigen development infection vaccine

Editors and affiliations

  • W. Evan Secor
    • 1
  • Daniel G. Colley
    • 2
  1. 1.Division of Parasitic DiseasesNational Center for Infectious Diseases, Centers for Disease Control and PreventionUSA
  2. 2.Center for Tropical and Emerging Global Diseases and Department of MicrobiologyUniversity of GeorgiaUSA

Bibliographic information