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Alzheimer’s Disease

Cellular and Molecular Aspects of Amyloid β

  • J. Robin Harris
  • Falk Fahrenholz

Part of the Subcellular Biochemistry book series (SCBI, volume 38)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Tom van Dooren, Ilse Dewachter, Peter Borghgraef, Fred van Leuven
    Pages 45-63
  3. Elżbieta Kojro, Falk Fahrenholz
    Pages 105-127
  4. Laura Morelli, Ayelén Bulloj, María Celeste Leal, Eduardo M. Castaño
    Pages 129-145
  5. Francisco José Muñoz, Montserrat Solé, Mireia Coma
    Pages 147-165
  6. Katsuhiko Yanagisawa
    Pages 179-202
  7. Math P. Cuajungco, Christopher J. Frederickson, Ashley I. Bush
    Pages 235-254
  8. Donald B. Carter
    Pages 255-272
  9. Miguel Calero, Agueda Rostagno, Blas Frangione, Jorge Ghiso
    Pages 273-298
  10. Nibaldo C. Inestrosa, Juan Paulo Sagal, Marcela Colombres
    Pages 299-317
  11. Gunter P. Eckert, W. G. Wood, W. E. Müller
    Pages 319-337
  12. Claudio Soto, Lisbell Estrada
    Pages 351-364
  13. Back Matter
    Pages 403-409

About this book

Introduction

This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-ß production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-ß oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ß-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-ß phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-ß, of direct relevance to Alzheimer’s disease.

 

Keywords

Alzheimer Calcium attention biochemistry enzymes proteins

Editors and affiliations

  • J. Robin Harris
    • 1
  • Falk Fahrenholz
    • 2
  1. 1.Institute of ZoologyUniversity of MainzMainzGermany
  2. 2.Institute of BiochemistryUniversity of MainzMainzGermany

Bibliographic information

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