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© 2019

Tau Biology

  • Akihiko Takashima
  • Benjamin Wolozin
  • Luc Buee

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1184)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Structure and Role of the Tau Molecule

    1. Front Matter
      Pages 1-1
    2. Michel Goedert, Maria Grazia Spillantini
      Pages 3-21
    3. Masato Hasegawa
      Pages 23-34
    4. Clément Danis, Elian Dupré, Xavier Hanoulle, Isabelle Landrieu, Alessia Lasorsa, João Filipe Neves et al.
      Pages 35-45
    5. Tara Tracy, Kathryn C. Claiborn, Li Gan
      Pages 47-55
    6. Maoping Tang, Jarreau Harrison, Carol A. Deaton, Gail V. W. Johnson
      Pages 57-68
  3. Tau Localization and Function

    1. Front Matter
      Pages 79-79
    2. Benjamin Combs, Rebecca L. Mueller, Gerardo Morfini, Scott T. Brady, Nicholas M. Kanaan
      Pages 81-95
    3. Diane P. Hanger, Despoina Goniotaki, Wendy Noble
      Pages 105-112
    4. Philip Regan, Kwangwook Cho
      Pages 113-121
    5. Zhi Ruan, Tsuneya Ikezu
      Pages 123-134
    6. Marie-Christine Galas, Eliette Bonnefoy, Luc Buee, Bruno Lefebvre
      Pages 135-143
    7. Ilie-Cosmin Stancu, Mattia Ferraiolo, Dick Terwel, Ilse Dewachter
      Pages 145-166
  4. Tau and Disease-Related Proteins

    1. Front Matter
      Pages 167-167
    2. Lauren Walker, Johannes Attems
      Pages 169-176
    3. Elena Rodriguez-Vieitez, Henrietta M. Nielsen
      Pages 177-186
    4. Gilbert Gallardo, David M. Holtzman
      Pages 187-203

About this book

Introduction

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons.  In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons.  Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death.  With the help of new technologies, researchers are now solving these long-standing questions.  In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.


Keywords

Tauopathies Neurofibrillary tangle NFT Neuronal death Brain aging Therapy Diagnosis

Editors and affiliations

  • Akihiko Takashima
    • 1
  • Benjamin Wolozin
    • 2
  • Luc Buee
    • 3
  1. 1.Department of Life SciencesGakushuin UniversityTokyoJapan
  2. 2.Department of Pharmacology and Experimental TherapeuticsBoston University School of MedicineBostonUSA
  3. 3.University of Lille, INSERM, CHU-Lille, Alzheimer & Tauopathies, LabEx DISTALZLilleFrance

About the editors

Akihiko Takashima

Gakushuin University, Dept Life Sci., Lab Alzheimers Dis., Japan


Benjamin Wolozin

Boston University, School of Med., Dept Pharmacol., USA


Luc Buee

University of Lille, CHU Lille, INSERM, Memory & Resources Res. Ctr., France



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