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© 2020

Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

Book

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.

Keywords

Epigenetics Chemical Reporter Histone Posttranslational Modifications Chromatin Structure Protein-protein interaction Immunoblotting analysis Metabolic labeling Chemical proteomics approach

Authors and affiliations

  1. 1.Department of ChemistryThe University of Hong KongHongkongChina

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