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Mitochondria in Health and in Sickness

  • Andrea Urbani
  • Mohan Babu
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1158)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Mara Zilocchi, Mauro Fasano, Tiziana Alberio
    Pages 17-44
  3. Alessio Soggiu, Paola Roncada, Luigi Bonizzi, Cristian Piras
    Pages 45-57
  4. Viviana Greco, Patrizia Longone, Alida Spalloni, Luisa Pieroni, Andrea Urbani
    Pages 71-82
  5. Zhuoran Wu, Ramy Malty, Mohamed Taha Moutaoufik, Qingzhou Zhang, Matthew Jessulat, Mohan Babu
    Pages 83-100
  6. Justina C. Wolters, Hjalmar P. Permentier, Barbara M. Bakker, Rainer Bischoff
    Pages 101-117
  7. Andrew J. Valente, Joao Fonseca, Fereshteh Moradi, Gregory Foran, Alexander Necakov, Jeffrey A. Stuart
    Pages 183-196
  8. Iman Al Khatib, Timothy E. Shutt
    Pages 217-246
  9. Vanessa F. Gonçalves
    Pages 247-255
  10. Mansur M. Naeem, Neal Sondheimer
    Pages 257-267

About this book

Introduction

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. 

Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

Keywords

Mitochondrial disease Mitochondrial dysfunction Mitochondrial health Mitochondrial metabolism Mitochondrial proteomics

Editors and affiliations

  • Andrea Urbani
    • 1
  • Mohan Babu
    • 2
  1. 1.Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario A. Gemelli – IRCCSRomeItaly
  2. 2.Department of BiochemistryUniversity of ReginaReginaCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-8367-0
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-8366-3
  • Online ISBN 978-981-13-8367-0
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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