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Genome-Wide Association Studies

  • Tatsuhiko Tsunoda
  • Toshihiro Tanaka
  • Yusuke Nakamura
Book

Table of contents

  1. Front Matter
    Pages i-ix
  2. Artem Lysenko, Keith A. Boroevich, Tatsuhiko Tsunoda
    Pages 1-20
  3. Kouichi Ozaki, Toshihiro Tanaka
    Pages 21-36
  4. Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi
    Pages 37-47
  5. Minako Imamura, Momoko Horikoshi, Shiro Maeda
    Pages 49-86
  6. Yosuke Omae, Katsushi Tokunaga
    Pages 145-174
  7. Hitoshi Zembutsu
    Pages 175-192
  8. Tatsuhiko Tsunoda
    Pages 193-209

About this book

Introduction

This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Keywords

Genotyping Human genome Pharmacogenomics Next-generation sequencing Common diseases Phenotypes Personalized medicine Precision medicine

Editors and affiliations

  • Tatsuhiko Tsunoda
    • 1
  • Toshihiro Tanaka
    • 2
  • Yusuke Nakamura
    • 3
  1. 1.Graduate School of ScienceThe University of TokyoTokyoJapan
  2. 2.BioResource Research CenterTokyo Medical and Dental UniversityTokyoJapan
  3. 3.Cancer Precision Medicine CenterJapanese Foundation for Cancer ResearchTokyoJapan

Bibliographic information

Industry Sectors
Biomedicine
Pharma
Biotechnology