Hyperbaric Oxygenation Therapy

Molecular Mechanisms and Clinical Applications

  • Nariyoshi Shinomiya
  • Yasufumi Asai

Table of contents

  1. Front Matter
    Pages i-vii
  2. Stress Responses of the Cell Under Hyperbaric/Hyperoxic Environment

    1. Front Matter
      Pages 1-1
    2. Nariyoshi Shinomiya
      Pages 3-20
    3. Nariyoshi Shinomiya
      Pages 21-41
  3. Application of Hyperbaric Oxygen to the Treatment of Intractable Diseases

    1. Front Matter
      Pages 53-53
    2. Yasufumi Asai, Hiroshi Dohgomori
      Pages 55-65
    3. Masayuki Kawashima, Takashi Yamaguchi, Hiroaki Tamura, Mahito Kawashima
      Pages 67-80
    4. Noriaki Yamada, Izumi Toyoda, Shinji Ogura
      Pages 81-103

About this book


This book focuses on hyperbaric oxygenation (HBO) therapy from the molecular biology perspective and its clinical applications, including molecular mechanisms of HBO’s positive effect on cellular function in hypoxic tissues.

HBO is a therapeutic tool that enhances oxygen supply to hypoxic tissues and improves wound healing/tissue remodeling. Currently HBO therapy is applied to a wide range of clinical cases, which include not only acute hypoxic diseases but also many chronic and refractory diseases involving tissue hypoxia or intractable infection. HBO therapy is a well-recognized regimen for many researchers and clinicians. 

The first half of the book outlines basic molecular mechanisms of HBO and their potential applications for clinical activities, while the second half describes the rationale behind introducing HBO therapy into suitable clinical cases and presents successful clinical reports. It is primarily written for HBO clinicians, physiologists and basic research scientists, but is also of interest to clinicians who have an interest in this field considering introducing HBO therapy.


Soft tissue injury Oxygen stress Molecular mechanism Stroke Tissue hypoxia

Editors and affiliations

  • Nariyoshi Shinomiya
    • 1
  • Yasufumi Asai
    • 2
  1. 1.Department of Integrative Physiology and Bio-Nano MedicineNational Defense Medical CollegeTokorozawaJapan
  2. 2.Hakodate Shintoshi HospitalHakodateJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2020
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-981-13-7835-5
  • Online ISBN 978-981-13-7836-2
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Surgery & Anesthesiology