Therapeutic Enzymes: Function and Clinical Implications

  • Nikolaos Labrou

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1148)

Table of contents

  1. Front Matter
    Pages i-viii
  2. M. Ângela Taipa, Pedro Fernandes, Carla C. C. R. de Carvalho
    Pages 1-24
  3. María Celeste Rodríguez, Natalia Ceaglio, Sebastián Antuña, María Belén Tardivo, Marina Etcheverrigaray, Claudio Prieto
    Pages 25-54
  4. Zhaoshuai Wang, Caihong Li, Yinan Wei
    Pages 105-114
  5. Xing Jing, Yan Hou, William Hallett, Chandrahas G. Sahajwalla, Ping Ji
    Pages 115-129
  6. Shubhrima Ghosh, Shahenvaz Alam, Anurag S. Rathore, S. K. Khare
    Pages 131-150
  7. Maristella Maggi, Claudia Scotti
    Pages 173-199
  8. Maria Luisa Bianchi, Silvia Vai
    Pages 201-232
  9. Dorien Dams, Yves Briers
    Pages 233-253
  10. Gregor Cornelius Weber, Bettina Alexandra Buhren, Holger Schrumpf, Johannes Wohlrab, Peter Arne Gerber
    Pages 255-277
  11. Gyanprakash A. Ketwaroo, David Y. Graham
    Pages 323-343
  12. Swaroop S. Kumar, Abdulhameed Sabu
    Pages 345-381
  13. Back Matter
    Pages 383-386

About this book


This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy.

This book covers mainly three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology: (i) overview of the production process and biochemical characterization of therapeutic enzymes, (ii) focuses upon the engineering strategies and delivery methods of therapeutic enzymes, (iii) clinical applications of selected therapeutic enzymes, including aspects on their mechanisms of action and information on safety, immunogenicity issues and various adverse events of the enzymes used for therapy.

The topic of this book is particularly relevant to academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.


Therapeutic Enzymes Recombinant Enzymes Protein Engineering Enzyme Therapy Enzyme Manufacturing

Editors and affiliations

  • Nikolaos Labrou
    • 1
  1. 1.Department of BiotechnologyAgricultural University of AthensAthensGreece

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