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Drug Transporters in Drug Disposition, Effects and Toxicity

  • Xiaodong Liu
  • Guoyu Pan
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1141)

Table of contents

  1. Front Matter
    Pages i-x
  2. Xiaodong Liu
    Pages 13-100
  3. Xiaodong Liu
    Pages 101-202
  4. Yaru Xue, Chenhui Ma, Imad Hanna, Guoyu Pan
    Pages 361-405
  5. Li Liu, Xiaodong Liu
    Pages 467-504
  6. Haneen Amawi, Hong-May Sim, Amit K. Tiwari, Suresh V. Ambudkar, Suneet Shukla
    Pages 549-580

About this book

Introduction

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

Keywords

ATP binding cassette transporters Solute carrier transporters Drug-drug interaction Blood-tissue barrier Multidrug-resistance

Editors and affiliations

  • Xiaodong Liu
    • 1
  • Guoyu Pan
    • 2
  1. 1.School of PharmacyChina Pharmaceutical UniversityNanjingChina
  2. 2.Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghaiChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-7647-4
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-7646-7
  • Online ISBN 978-981-13-7647-4
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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