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Leukemia Stem Cells in Hematologic Malignancies

  • Haojian Zhang
  • Shaoguang Li
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1143)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Lindsay M. Gurska, Kristina Ames, Kira Gritsman
    Pages 1-39
  3. Xueqin Xie, Mengdie Feng, Qifan Wang, Jiazhen Wang, Rong Yin, Yicun Li et al.
    Pages 41-57
  4. Dan Huang, Chiqi Chen, Xiaoxin Hao, Hao Gu, Li Xie, Zhuo Yu et al.
    Pages 59-74
  5. Hengyou Weng, Huilin Huang, Jianjun Chen
    Pages 75-93
  6. Kanak Joshi, Lei Zhang, Peter Breslin S.J., Jiwang Zhang
    Pages 95-128
  7. Persio Dello Sbarba, Giulia Cheloni
    Pages 129-145
  8. Wenjun Zhang, Guangming Wang, Aibin Liang
    Pages 147-171
  9. Jing Xu, Xiaohang Hang, Baohong Wu, Chong Chen, Yu Liu
    Pages 173-189
  10. Yi Shan, Ngoc DeSouza, Qiang Qiu, Shaoguang Li
    Pages 191-215
  11. Satoko Matsueda, Thinle Chodon, Richard C. Koya
    Pages 217-229

About this book

Introduction

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Keywords

leukemia stem cells blood cancer targeted therapy drug resistance disease relapse

Editors and affiliations

  • Haojian Zhang
    • 1
  • Shaoguang Li
    • 2
  1. 1.Medical Research InstituteWuhan UniversityWuhanChina
  2. 2.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-7342-8
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-7341-1
  • Online ISBN 978-981-13-7342-8
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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