Antimicrobial Peptides

Basics for Clinical Application

  • Katsumi Matsuzaki

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1117)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Mechanisms of Antimicrobial Action

  4. Other Activities of AMPs

    1. Front Matter
      Pages 91-91
    2. Wilmar Correa, Lena Heinbockel, Guillermo Martinez-de-Tejada, Susana Sánchez, Patrick Garidel, Tobias Schürholz et al.
      Pages 111-129
    3. A. L. Hilchie, D. W. Hoskin, M. R. Power Coombs
      Pages 131-147
    4. Anne M. van der Does, Pieter S. Hiemstra, Neeloffer Mookherjee
      Pages 149-171
  5. Towards Clinical Applications

    1. Front Matter
      Pages 173-173
    2. Guangshun Wang, Jayaram Lakshmaiah Narayana, Biswajit Mishra, Yingxia Zhang, Fangyu Wang, Chunfeng Wang et al.
      Pages 215-240
    3. Hawraa Shahrour, Raquel Ferrer-Espada, Israa Dandache, Sergio Bárcena-Varela, Susana Sánchez-Gómez, Ali Chokr et al.
      Pages 257-279
    4. Fabíola Costa, Cátia Teixeira, Paula Gomes, M. Cristina L. Martins
      Pages 281-298
  6. Back Matter
    Pages 299-304

About this book


This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.


Mechanism of action Antisepsis agent Anticancer agent Clinical application Peptide translocation

Editors and affiliations

  • Katsumi Matsuzaki
    • 1
  1. 1.Graduate School of Pharmaceutical SciencesKyoto UniversitySakyo-kuJapan

Bibliographic information

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