© 2019

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

  • Mousumi Mutsuddi
  • Ashim Mukherjee

Table of contents

  1. Front Matter
    Pages i-x
  2. Vartika Sharma, Abhinava K. Mishra, Mousumi Mutsuddi, Ashim Mukherjee
    Pages 1-36
  3. Aishwarya S Mandya, Rajit Narayanan Cheramangalam, Manish Jaiswal
    Pages 55-88
  4. Kriti Chaplot, Anuradha Ratnaparkhi, Girish Ratnaparkhi
    Pages 131-162
  5. Priya Lakra, Namita Agrawal
    Pages 163-183
  6. Nalani Sachan, Mousumi Mutsuddi, Ashim Mukherjee
    Pages 185-221
  7. Nisha, Pragati, Shweta Tandon, Aqsa, Prerna Aggarwal, Surajit Sarkar
    Pages 223-250
  8. Catherine J. Yeates, Ankita Sarkar, Madhuri Kango-Singh, Amit Singh
    Pages 251-277
  9. Souradip Chatterjee, Pradeep Kumar Bhaskar, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 279-310
  10. Rituparna Das, Mouli Chakraborty, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 335-371
  11. Bhawana Maurya, Satya Surabhi, Pranjali Pandey, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 373-403
  12. Cristina Solana-Manrique, María Dolores Moltó, Pablo Calap-Quintana, Francisco José Sanz, José Vicente Llorens, Nuria Paricio
    Pages 433-467

About this book


This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.


Drosophila Neurodegeneration Molecular mechanisms Genetic screen Model system

Editors and affiliations

  • Mousumi Mutsuddi
    • 1
  • Ashim Mukherjee
    • 2
  1. 1.Department of Molecular and Human GeneticsBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of Molecular and Human GeneticsBanaras Hindu UniversityVaranasiIndia

About the editors

Dr. Mousumi Mutsuddi is a faculty in the Department of Molecular and Human Genetics, Banaras Hindu University. She was earlier a scientist at Broad Institute, MIT. She has been visiting scientist at NIH, Whitehead Institute of Biomedical Research, MIT, and University of Valencia etc. She has close to three decades of research experience and has contributed immensely to the understanding of molecular basis of neurodegenerative disease, congenital ocular disorders and apoptosis. Her research group has identified novel RNA binding proteins that depletes pathogenic non-coding SCA8 transcripts as well as identified a novel RNA helicase, Maheshvara whose human orthologue is vital for CNS development. Her research findings have been published in reputed journals like Current Biology, American Journal of Human Genetics, and Human Mutation etc. She has delivered invited lectures in several international meetings and her research contributions have won her recognitions and awards from apical organizations of India like Department of Biotechnology and Indian National Science Academy. 

Dr. Ashim Mukherjee is a Professor in the Department of Molecular and Human Genetics, Banaras Hindu University, India. He has almost thirty years of research experience in the field of Drosophila Genetics and Molecular Biology. He has worked at premier research institutes like Harvard Medical School, Boston, USA. He has identified several novel interacting partners involved in different aspects of Notch signaling. His research findings have been published in renowned journals like Nature Cell Biology, Genome Research, Current Biology, Genetics, and Development etc. Department of Science and Technology, Department of Biotechnology, Government of India has funded research work in his laboratory. Dr. Mukherjee is member of the Drosophila Board of India, life member of Indian Society of Cell Biology and the Indian Society of Developmental Biology. He is also member in the editorial board of several journals.

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