Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

  • Mousumi Mutsuddi
  • Ashim Mukherjee

Table of contents

  1. Front Matter
    Pages i-x
  2. Vartika Sharma, Abhinava K. Mishra, Mousumi Mutsuddi, Ashim Mukherjee
    Pages 1-36
  3. Aishwarya S Mandya, Rajit Narayanan Cheramangalam, Manish Jaiswal
    Pages 55-88
  4. Kriti Chaplot, Anuradha Ratnaparkhi, Girish Ratnaparkhi
    Pages 131-162
  5. Priya Lakra, Namita Agrawal
    Pages 163-183
  6. Nalani Sachan, Mousumi Mutsuddi, Ashim Mukherjee
    Pages 185-221
  7. Nisha, Pragati, Shweta Tandon, Aqsa, Prerna Aggarwal, Surajit Sarkar
    Pages 223-250
  8. Catherine J. Yeates, Ankita Sarkar, Madhuri Kango-Singh, Amit Singh
    Pages 251-277
  9. Souradip Chatterjee, Pradeep Kumar Bhaskar, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 279-310
  10. Rituparna Das, Mouli Chakraborty, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 335-371
  11. Bhawana Maurya, Satya Surabhi, Pranjali Pandey, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 373-403
  12. Cristina Solana-Manrique, María Dolores Moltó, Pablo Calap-Quintana, Francisco José Sanz, José Vicente Llorens, Nuria Paricio
    Pages 433-467

About this book


This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.


Drosophila Neurodegeneration Molecular mechanisms Genetic screen Model system

Editors and affiliations

  • Mousumi Mutsuddi
    • 1
  • Ashim Mukherjee
    • 2
  1. 1.Department of Molecular and Human GeneticsBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of Molecular and Human GeneticsBanaras Hindu UniversityVaranasiIndia

Bibliographic information

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