© 2018

Synthesis of Therapeutic Oligonucleotides

  • Satoshi Obika
  • Mitsuo Sekine

Table of contents

  1. Front Matter
    Pages i-viii
  2. Synthesis of Natural Oligonucleotides

    1. Front Matter
      Pages 1-1
    2. Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
      Pages 3-16
    3. Hidetoshi Kitagawa
      Pages 67-81
    4. Satoshi Katayama, Kunihiro Hirai
      Pages 83-95
    5. Eduardo Paredes, Tatsuya Konishi
      Pages 97-112
  3. Synthesis and Properties of Artificial Oligonucleotides

    1. Front Matter
      Pages 113-113
    2. Noriko Saito-Tarashima, Akira Matsuda, Noriaki Minakawa
      Pages 147-169
    3. Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
      Pages 187-199
    4. Noriaki Minakawa, Noriko Saito-Tarashima, Akira Matsuda
      Pages 233-252
    5. Yohei Nukaga, Takeshi Wada
      Pages 271-284

About this book


This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.


Therapeutic oligonucleotide Chemical modification Sugar Modification Artificial Oligonucleotides RNA Synthesis Natural Oligonucleotides

Editors and affiliations

  • Satoshi Obika
    • 1
  • Mitsuo Sekine
    • 2
  1. 1.Osaka UniversitySuitaJapan
  2. 2.Tokyo Institute of TechnologyYokohamaJapan

About the editors

Satoshi Obika, Osaka University, Japan

Mitsuo Sekine, Tokyo Institute of Technology, Japan

Bibliographic information

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