© 2019

Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

Current and Future Trends

  • Neil H. Shear
  • Roni P. Dodiuk-Gad

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

  3. Pathomechanisms of Cutaneous Adverse Drug Reactions

    1. Front Matter
      Pages 21-21
    2. Chuang-Wei Wang, Shuen-Iu Hung
      Pages 23-37
    3. Ren-You Pan, Chun-Bing Chen, Wen-Hung Chung
      Pages 39-53
    4. Tetsuo Shiohara, Yoko Kano, Yoshiko Mizukawa, Yumi Aoyama
      Pages 55-65
  4. Clinical Perspectives of Cutaneous Adverse Drug Reactions

    1. Front Matter
      Pages 75-75
    2. Sima Halevy
      Pages 105-122
    3. Daniel F. Carr
      Pages 123-129
    4. Jennifer Wu, Alina Markova, Mario E. Lacouture
      Pages 131-173
    5. Ilan Fridental, Yaron Finkelstein
      Pages 175-184
    6. James W. S. Young
      Pages 185-195
    7. Rannakoe J. Lehloenya, Jonny Peter
      Pages 197-205
    8. Jonny Peter, Rannakoe J. Lehloenya
      Pages 207-215
  5. Approach to the Patient with a Cutaneous Adverse Drug Reaction

    1. Front Matter
      Pages 217-217
    2. Cristina Olteanu, Neil H. Shear, Roni P. Dodiuk-Gad
      Pages 219-226

About this book


This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development.

The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.


Drug Reaction with Eosinophilia and Systemic Symptoms DRESS Drug-induced Hypersensitivity Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Acute Generalised Exanthematous Pustulosis Dermatologic side effects

Editors and affiliations

  • Neil H. Shear
    • 1
  • Roni P. Dodiuk-Gad
    • 2
  1. 1.University of Toronto Medical School, Sunnybrook Health Sciences CentreTorontoCanada
  2. 2.Department of DermatologyEmek Medical CenterAfulaIsrael

About the editors

Dr. Neil H. Shear is a University of Toronto Professor of Medicine (Internal Medicine, Dermatology, Clinical Pharmacology and Toxicology) and Head of the Drug Safety Clinic at Sunnybrook Health Sciences Centre.  He is the president of the Canadian Dermatology Association and past-president of the Canadian Society for Clinical Pharmacology and the Canadian Dermatology Foundation.  He chaired the University Division of Dermatology from 2001 to 2017.

His research is in all aspects of Drug Safety. He has published over 350 peer-reviewed papers, authored/co-authored over 60 textbook chapters, and has served on many journal editorial boards.  He is currently the Editor of Litt’s Drug Eruption Reference Manual.  He has recently been awarded the Practitioner-of-the-Year award from the Canadian Dermatology Association.

Dr. Roni P. Dodiuk-Gad is the Vice-head of the Dermatology Department, Emek Medical Center, an Assistant Professor in the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Israel and a Research Fellow at the University of Toronto, Canada. Her research interests are primarily adverse cutaneous drug reactions and Darier disease. She conducted 3 years of clinical fellowship in ‘Advanced Medical Dermatology’ under the supervision of Professor Neil H. Shear and upon completion became his research fellow. She has been interested in the topic of adverse cutaneous drug reactions since the beginning of her residency in dermatology in 2003; she was a member of the RegisCAR research team, has published many book chapters on the topic and was in the organizing committee of recent important conferences on the topic. She received numerous academic awards; in 2015 in the 23rd World Congress of Dermatology, she was invited to give a Rising Star Talk and in 2018, she was chosen as one of the 40 most promising young graduated of the Technion - Institute of Technology, Israel.

Bibliographic information

  • Book Title Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
  • Book Subtitle Current and Future Trends
  • Editors Neil H. Shear
    Roni P. Dodiuk-Gad
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Adis, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-13-1488-9
  • Softcover ISBN 978-981-13-4641-5
  • eBook ISBN 978-981-13-1489-6
  • Edition Number 1
  • Number of Pages XII, 314
  • Number of Illustrations 4 b/w illustrations, 91 illustrations in colour
  • Topics Drug Safety and Pharmacovigilance
  • Buy this book on publisher's site
Industry Sectors


“The audience encompasses physicians such as dermatologists and critical care specialists/burn unit intensivists … the book will provide any physician with insights into the most common drugs, patient populations, and sequelae of these reactions. Pharmacists also would find this book useful to better understand these reactions.” (Patrick J. McDonnell, Doody's Book Reviews, June 07, 2019)