Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

Current and Future Trends

  • Neil H. Shear
  • Roni P. Dodiuk-Gad

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

  3. Pathomechanisms of Cutaneous Adverse Drug Reactions

    1. Front Matter
      Pages 21-21
    2. Chuang-Wei Wang, Shuen-Iu Hung
      Pages 23-37
    3. Ren-You Pan, Chun-Bing Chen, Wen-Hung Chung
      Pages 39-53
    4. Tetsuo Shiohara, Yoko Kano, Yoshiko Mizukawa, Yumi Aoyama
      Pages 55-65
  4. Clinical Perspectives of Cutaneous Adverse Drug Reactions

    1. Front Matter
      Pages 75-75
    2. Sima Halevy
      Pages 105-122
    3. Daniel F. Carr
      Pages 123-129
    4. Jennifer Wu, Alina Markova, Mario E. Lacouture
      Pages 131-173
    5. Ilan Fridental, Yaron Finkelstein
      Pages 175-184
    6. James W. S. Young
      Pages 185-195
    7. Rannakoe J. Lehloenya, Jonny Peter
      Pages 197-205
    8. Jonny Peter, Rannakoe J. Lehloenya
      Pages 207-215
  5. Approach to the Patient with a Cutaneous Adverse Drug Reaction

    1. Front Matter
      Pages 217-217
    2. Cristina Olteanu, Neil H. Shear, Roni P. Dodiuk-Gad
      Pages 219-226
    3. Mari Orime, Riichiro Abe
      Pages 227-235
    4. Lois La Grenade, Maja Mockenhaupt, Elizabeth Phillips
      Pages 265-272
  6. Epilogue

    1. Front Matter
      Pages 273-273
    2. Elizabeth Ergen, Jason Trubiano, Jonny Peter, Elizabeth Phillips
      Pages 275-282
    3. Alina G. Bridges, Kevin Brough
      Pages 283-314

About this book


This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development.

The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.


Drug Reaction with Eosinophilia and Systemic Symptoms DRESS Drug-induced Hypersensitivity Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Acute Generalised Exanthematous Pustulosis Dermatologic side effects

Editors and affiliations

  • Neil H. Shear
    • 1
  • Roni P. Dodiuk-Gad
    • 2
  1. 1.University of Toronto Medical School, Sunnybrook Health Sciences CentreTorontoCanada
  2. 2.Department of DermatologyEmek Medical CenterAfulaIsrael

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Adis, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-13-1488-9
  • Online ISBN 978-981-13-1489-6
  • Buy this book on publisher's site
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