© 2018

Role of Tyrosine Kinases in Gastrointestinal Malignancies

  • Ganji Purnachandra Nagaraju

Table of contents

  1. Front Matter
    Pages i-xv
  2. Ranjeet Kumar, Akriti Gupta Jain, Mamoon Ur Rashid, Saeed Ali, Neelam Khetpal, Ishtiaq Hussain et al.
    Pages 1-14
  3. Neelam Khetpal, Saeed Ali, Ranjeet Kumar, Mamoon Ur Rashid, Sarfraz Ahmad
    Pages 29-56
  4. Saimila Momin, Ganji Purnachandra Nagaraju
    Pages 57-61
  5. Tapan K. Barik, Surya N. Swain
    Pages 71-81
  6. Gowru Srivani, Shipra Reddy Bethi, Sheik Aliya, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 83-96
  7. Vidya Mukhund, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 97-105
  8. Mamoon Ur Rashid, Ishtiaq Hussain, Sundas Jehanzeb, Saeed Ali, Akriti Gupta Jain, Ranjeet Kumar et al.
    Pages 115-140
  9. Begum Dariya, Neha Merchant, Sheik Aliya, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 141-170
  10. Saimila Momin, Ganji Purnachandra Nagaraju
    Pages 171-178
  11. Siva K. P. Konduru, Santoshi Muppala
    Pages 179-190
  12. Allyson E. Koyen, Geraldine Nabeta, Stevin Bienfait, Ashley J. Schlafstein, David S. Yu, Waaqo Daddacha
    Pages 225-234
  13. Suvani Subhadarshini, Neha Merchant, Ganji Seeta Rama Raju
    Pages 235-241

About this book


The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy.

Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.


Tyrosine kinases Gastrointestinal malignancies Tyrosine kinase receptors Tyrosine Kinase inhibitors Drug resistance

Editors and affiliations

  • Ganji Purnachandra Nagaraju
    • 1
  1. 1.Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer InstituteEmory UniversityAtlantaUSA

About the editors

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. He obtained his MSc and his Ph.D., both in biotechnology, from Sri Venkateswara University, Tirupati, Andhra Pradesh, India. His research focuses on translational projects related to gastrointestinal malignancies. He has published over 65 research articles in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. He has also served as an editorial board member of several internationally recognized academic journals. He is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He has received several prestigious international awards and holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society, and the American Association of Cancer Research (AACR).

Bibliographic information

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