Muscle Atrophy

  • Junjie Xiao

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1088)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Shengguang Ding, Qiying Dai, Haitao Huang, Yiming Xu, Chongjun Zhong
      Pages 3-19
  3. Basic Aspects of Muscle Atrophy

    1. Front Matter
      Pages 21-21
    2. Dragos Cretoiu, Luciana Pavelescu, Florentina Duica, Mihaela Radu, Nicolae Suciu, Sanda Maria Cretoiu
      Pages 23-46
    3. Adrian Dumitru, Beatrice Mihaela Radu, Mihai Radu, Sanda Maria Cretoiu
      Pages 73-92
    4. Leonard Năstase, Dragos Cretoiu, Silvia Maria Stoicescu
      Pages 93-106
  4. Molecular Mechanisms of Muscle Atrophy

    1. Front Matter
      Pages 107-107
    2. Louk T. Timmer, Willem M. H. Hoogaars, Richard T. Jaspers
      Pages 109-137
    3. Jocemar Ilha, Caroline Cunha do Espírito-Santo, Gabriel Ribeiro de Freitas
      Pages 139-151
    4. Ana Isabel Martín, Teresa Priego, Asunción López-Calderón
      Pages 207-233
    5. Yongqin Li, Xiangmin Meng, Guoping Li, Qiulian Zhou, Junjie Xiao
      Pages 249-266
    6. Anastasia Thoma, Adam P. Lightfoot
      Pages 267-279
    7. Giorgos K. Sakellariou, McDonagh Brian
      Pages 281-306
  5. Muscle Atrophy in Diseases and Aging

    1. Front Matter
      Pages 327-327
    2. Jian Yang, Richard Y. Cao, Qing Li, Fu Zhu
      Pages 329-346
    3. Yu Zhang, Xiangbin Pan, Yi Sun, Yong-jian Geng, Xi-Yong Yu, Yangxin Li
      Pages 347-368
    4. Isadora Rebolho Sisto, Melina Hauck, Rodrigo Della Méa Plentz
      Pages 369-391
    5. Jociane Schardong, Miriam Allein Zago Marcolino, Rodrigo Della Méa Plentz
      Pages 393-412
    6. Meiyi Song, Lu Xia, Qi Liu, Mengxue Sun, Fei Wang, Changqing Yang
      Pages 413-433
  6. Diagnosis, Drugs and Promising Agents of Muscle Atrophy

    1. Front Matter
      Pages 435-435
    2. Kunihiro Sakuma, Akihiko Yamaguchi
      Pages 463-481
    3. Daniel John Owens
      Pages 483-495
    4. Sanda Maria Cretoiu, Corina Aurelia Zugravu
      Pages 497-528
    5. Liang Shen, Xiangmin Meng, Zhongrong Zhang, Tianhui Wang
      Pages 529-545
  7. Treatment Strategies of Muscle Atrophy

    1. Front Matter
      Pages 547-547
    2. Michelle Rabelo, Renata Viana Brigido de Moura Jucá, Lidiane Andréa Oliveira Lima, Henrique Resende-Martins, Antônio Padilha Lanari Bó, Charles Fattal et al.
      Pages 561-583
    3. Helmut Kern, Paolo Gargiulo, Amber Pond, Giovanna Albertin, Andrea Marcante, Ugo Carraro
      Pages 585-591
  8. Future Prospects

    1. Front Matter
      Pages 603-603
    2. Richard Y. Cao, Jin Li, Qiying Dai, Qing Li, Jian Yang
      Pages 605-624

About this book


The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.


Muscle atrophy Muscle wasting Skeletal muscle Mitochondria signaling Noncoding RNAs

Editors and affiliations

  • Junjie Xiao
    • 1
  1. 1.Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life ScienceShanghai UniversityShanghaiChina

Bibliographic information

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