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© 2018

Neurotoxicity of Aluminum

  • Qiao Niu
  • reviewing the cutting-edge research development linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease

  • focusing on aluminum levels in brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta

  • highlighting detailed mechanisms of aluminum in oxidative stress and cell death, especially about apoptosis and necroptosis

Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1091)

About this book

Introduction

This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. 


Keywords

Aluminum Neurotoxicity Cognitive impairment Pathological features Cell death Alzheimer’s disease

Editors and affiliations

  • Qiao Niu
    • 1
  1. 1.Department of Occupational Health, School of Public HealthShanxi Medical UniversityTaiyuanChina

About the editors

Dr. Qiao Niu is a professor and director of the Department of Occupational Health, School of Public Health, Shanxi Medical University. He is also director of the Institute of Preventive Medicine at the same university. Dr. Niu is executive director of the Chinese Society for Toxicology, and of the Labor Health and Occupational Disease Branch of the Chinese Preventive Medicine Association. His research focuses on neurotoxicology, an area in which he has published more than 100 research articles.

Bibliographic information

  • Book Title Neurotoxicity of Aluminum
  • Editors Qiao Niu
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI https://doi.org/10.1007/978-981-13-1370-7
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-13-1369-1
  • Softcover ISBN 978-981-13-4621-7
  • eBook ISBN 978-981-13-1370-7
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VII, 191
  • Number of Illustrations 12 b/w illustrations, 13 illustrations in colour
  • Topics Neurosciences
    Pharmacology/Toxicology
    Neurobiology
  • Buy this book on publisher's site
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