Neurotoxicity of Aluminum

  • Qiao Niu

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1091)

About this book


This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. 


Aluminum Neurotoxicity Cognitive impairment Pathological features Cell death Alzheimer’s disease

Editors and affiliations

  • Qiao Niu
    • 1
  1. 1.Department of Occupational Health, School of Public HealthShanxi Medical UniversityTaiyuanChina

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