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Non-coding RNAs in Complex Diseases

A Bioinformatics Perspective

  • Xia Li
  • Juan Xu
  • Yun Xiao
  • Shangwei Ning
  • Yunpeng Zhang

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1094)

Table of contents

  1. Front Matter
    Pages i-x
  2. Shangwei Ning, Xia Li
    Pages 1-7
  3. Yun Xiao, Jing Hu, Wenkang Yin
    Pages 9-18
  4. Yun Xiao, Min Yan, Chunyu Deng, Hongying Zhao
    Pages 19-28
  5. Shangwei Ning, Yunpeng Zhang
    Pages 39-48
  6. Yun Xiao, Jinyuan Xu, Wenkang Yin
    Pages 65-75
  7. Juan Xu, Jing Bai, Jun Xiao
    Pages 77-86
  8. Yongsheng Li, Caiqin Huo, Xiaoyu Lin, Juan Xu
    Pages 97-108
  9. Wei Jiang, Yingli Lv, Shuyuan Wang
    Pages 109-115
  10. Juan Xu, Zishan Wang, Xiyun Jin, Lili Li, Tao Pan
    Pages 117-126

About this book

Introduction

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.

Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Keywords

RNA bioinformatics lncRNA-disease associations non-coding RNAs ncRNA genome-wide discovery computational biology

Editors and affiliations

  • Xia Li
    • 1
  • Juan Xu
    • 2
  • Yun Xiao
    • 3
  • Shangwei Ning
    • 4
  • Yunpeng Zhang
    • 5
  1. 1.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbin, HeilongjiangChina
  2. 2.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbinChina
  3. 3.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbinChina
  4. 4.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbinChina
  5. 5.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbinChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-0719-5
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-0718-8
  • Online ISBN 978-981-13-0719-5
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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