© 2018

HIV Vaccines and Cure

The Path Towards Finding an Effective Cure and Vaccine

  • Linqi Zhang
  • Sharon R. Lewin


  • Providing a comprehensive review of the major barriers to HIV cure and vaccine

  • Covering the fundamental virology and immunology of HIV

  • Discussing the challenges related to development of HIV vaccine and its clinical trials


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1075)

Table of contents

  1. Front Matter
    Pages i-xv
  2. HIV Vaccines

    1. Front Matter
      Pages 1-1
    2. Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan
      Pages 3-30
    3. Beatriz Mothe, Christian Brander
      Pages 31-51
    4. Zhiwei Chen
      Pages 97-124
    5. M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen
      Pages 125-162
  3. HIV Cure

    1. Front Matter
      Pages 163-163
    2. Julia Marsh Sung, David M. Margolis
      Pages 165-185
    3. Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell et al.
      Pages 187-212
    4. Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión
      Pages 213-239
    5. James B. Whitney, R. Brad Jones
      Pages 241-263
    6. Bethany A. Horsburgh, Sarah Palmer
      Pages 265-284
    7. Thomas Aagaard Rasmussen, Ole S. Søgaard
      Pages 285-318

About this book


This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.


HIV Cure Latency Vaccine Antibody

Editors and affiliations

  • Linqi Zhang
    • 1
  • Sharon R. Lewin
    • 2
  1. 1.Comprehensive AIDS Research Center, School of MedicineTsinghua UniversityBeijingChina
  2. 2.The Peter Doherty Institute for Infection and ImmunityUniversity of Melbourne and Royal Melbourne HospitalMelbourneAustralia

About the editors

Dr. Linqi Zhang is a professor of Department of Basic Medical Sciences, and the director of Comprehensive AIDS Research Center, Tsinghua University. He is also an adjunct professor of Peking Union Medical College, China. Prof. Zhang was the Chief Scientist for the National Key Basic Research Projects of China “HIV Biology and its Immune Responses”. His research focuses on pathogenesis of HIV-1 and vaccine development against HIV-1. He has published more than 100 research articles on international journals in this field.

Dr. Sharon Lewin is a professor of Medicine at the University of Melbourne and the inaugural director of the Peter Doherty Institute for Infection and Immunity, a joint venture of the University of Melbourne and Royal Melbourne Hospital. She is a consultant physician at the Alfred Hospital and a practitioner fellow funded by the National Health and Medical Research Council of Australia. Prof. Lewin’s research focuses on understanding how HIV persists on antiretroviral therapy, developing early clinical trials to achieve a cure for HIV and understanding how HIV interacts with other viruses such as hepatitis B virus. She has published more than 250 research articles in these fields.

Bibliographic information

  • Book Title HIV Vaccines and Cure
  • Book Subtitle The Path Towards Finding an Effective Cure and Vaccine
  • Editors Linqi Zhang
    Sharon R. Lewin
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-13-0483-5
  • Softcover ISBN 978-981-13-4428-2
  • eBook ISBN 978-981-13-0484-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XV, 318
  • Number of Illustrations 5 b/w illustrations, 16 illustrations in colour
  • Topics Virology
    Animal Models
  • Buy this book on publisher's site
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