© 2018

Glucose-sensing Receptor in Pancreatic Beta-cells

  • Itaru Kojima

Table of contents

About this book


Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.”

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.

The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”.

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. 


Insulin secretion Diabetes Sweet Taste Receptor Glucoreceptor Metabolism

Editors and affiliations

  • Itaru Kojima
    • 1
  1. 1.Institute for Molecular & Cellular RegulationGunma UniversityMaebashiJapan

About the editors

Itaru Kojima, M.D. Professor Emeritus                                               

Institute for Molecular & Cellular Regulation, Gunma University 

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