Molecular Dynamics Analyses of Prion Protein Structures

The Resistance to Prion Diseases Down Under

  • Jiapu Zhang

Part of the Focus on Structural Biology book series (FOSB, volume 10)

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Jiapu Zhang
    Pages 1-12
  3. Part I

    1. Front Matter
      Pages 13-15
    2. Jiapu Zhang
      Pages 17-66
    3. Jiapu Zhang
      Pages 67-79
    4. Jiapu Zhang
      Pages 81-98
    5. Jiapu Zhang
      Pages 99-116
    6. Jiapu Zhang
      Pages 117-152
  4. Part II

    1. Front Matter
      Pages 153-154
    2. Jiapu Zhang
      Pages 167-190
    3. Jiapu Zhang
      Pages 191-203
  5. Part III

    1. Front Matter
      Pages 205-206
    2. Jiapu Zhang
      Pages 207-243
    3. Jiapu Zhang
      Pages 263-270
  6. Part IV

    1. Front Matter
      Pages 271-271
    2. Jiapu Zhang
      Pages 297-303
  7. Part V

  8. Back Matter
    Pages 355-375

About this book


Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.   

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.


Prion Protein Structure Molecular Dynamics Simulation Structural Dynamics Molecular Structure Prion Infection

Authors and affiliations

  • Jiapu Zhang
    • 1
  1. 1.Faculty of Science and TechnologyThe Federation University AustraliaMount HelenAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-981-10-8814-8
  • Online ISBN 978-981-10-8815-5
  • Series Print ISSN 1571-4853
  • Series Online ISSN 1571-4853
  • Buy this book on publisher's site
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