© 2018

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

  • Akinori Akaike
  • Shun Shimohama
  • Yoshimi Misu
  • Summarizes and enriches understanding of the novel aspects of nicotinic acetylcholine receptor (nAChR) functions in the CNS

  • Professionals and scholars alike will find it a handy up-to-date overview of basic and clinical studies of nAChRs for the treatment of neurodegenerative diseases

  • This Open Access Book has an interdisciplinary appeal and will engage scholars in field of drug innovation

Open Access

Table of contents

  1. Front Matter
    Pages i-x
  2. Akinori Akaike, Yasuhiko Izumi
    Pages 1-15 Open Access
  3. Masashi Ueda, Yuki Matsuura, Ryosuke Hosoda, Hideo Saji
    Pages 17-44 Open Access
  4. Ikunobu Muramatsu, Takayoshi Masuoka, Junsuke Uwada, Hatsumi Yoshiki, Takashi Yazama, Kung-Shing Lee et al.
    Pages 45-58 Open Access
  5. Toshiaki Kume, Yuki Takada-Takatori
    Pages 59-71 Open Access
  6. Norimitsu Morioka, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
    Pages 73-88 Open Access
  7. Atsumi Nitta, Hiroshi Noike, Kazuyuki Sumi, Hajime Miyanishi, Takuya Tanaka, Kazuya Takaoka et al.
    Pages 89-111 Open Access
  8. Hiroshi Katsuki, Kosei Matsumoto
    Pages 113-136 Open Access
  9. Kohji Fukunaga, Yasushi Yabuki
    Pages 159-171 Open Access
  10. Nobuya Kitaguchi, Kazunori Kawaguchi, Kazuyoshi Sakai
    Pages 173-191 Open Access

About this book


This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

This book is published with open access under a CC BY 4.0 license.


Alzheimer’s disease Neurodegenerative diseases Nicotine Transporter Glia Open Access

Editors and affiliations

  • Akinori Akaike
    • 1
  • Shun Shimohama
    • 2
  • Yoshimi Misu
    • 3
  1. 1.Department of Pharmacology, Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan
  2. 2.Department of Neurology, School of MedicineSapporo Medical UniversitySapporoJapan
  3. 3.Graduate School of MedicineYokohama City UniversityYokohamaJapan

About the editors

Akinori Akaike

Department of Pharmacology, Kyoto University, Japan


Shun Shimohama

Department of Neurology, Sapporo Medical University School of Medicine, Japan


Yoshimi Misu

Graduate School of Medicine, Yokohama City University, Japan

Bibliographic information

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