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© 2018

Biosensors Based on Sandwich Assays

  • Fan Xia
  • Xiaojin Zhang
  • Xiaoding Lou
  • Quan Yuan

Benefits

  • Provides a comprehensive description of the fundamentals and applications of biosensors based on sandwich assays

  • Addresses the technical aspects of biosensors based on sandwich assays

  • Describes the design and applications of biosensors based on sandwich assays, highlighting their extraordinary analytical specificity and sensitivity

  • Discusses the problems of biosensors based on sandwich assays used in clinic diagnostics

Book

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Xiaojin Zhang, Fan Xia
    Pages 1-13
  3. Xiaoqing Yi, Rui Liu, Xiaoding Lou, Fan Xia
    Pages 15-27
  4. Fujian Huang, Fan Xia
    Pages 29-45
  5. Hui Li, Shaoguang Li, Fan Xia
    Pages 47-68
  6. Xiaoxia Hu, Quan Yuan
    Pages 93-106
  7. Xinwen Liu, Quan Yuan
    Pages 107-125
  8. Meihua Lin, Xiaolei Zuo
    Pages 127-147
  9. Yu Dai, Xiaojin Zhang, Fan Xia
    Pages 167-182
  10. Shaoguang Li, Hui Li, Fan Xia
    Pages 183-197
  11. Xiaojin Zhang, Fan Xia
    Pages 199-216
  12. Fan Xia, Xiaojin Zhang, Xiaoding Lou, Quan Yuan
    Pages E1-E1

About this book

Introduction

This book shows the various sandwich assays that are constructed from recognition molecules, such as antibodies, oligonucleotide sequences and aptamers, developed as a result of nano- and biotechnology advances. It consists of ten chapters presenting interesting examples of these assays, organized according to the type of analytic methods (colorimetric, fluorescence, electrochemical, etc.) and detected objects (protein, nucleic acid, small-molecule, ion, etc.). It also includes a chapter discussing the introduction of sandwich assays as biosensors for the detection of a range of targets. It is an interesting and useful resource for a wide readership in various fields of chemical science and nanotechnology.

Keywords

Analytic methods Biomolecule detection Clinic diagnostics Recognition molecules Sandwich assays Signaling markers Specificity and sensitivity Supersandwich assays

Editors and affiliations

  • Fan Xia
    • 1
  • Xiaojin Zhang
    • 2
  • Xiaoding Lou
    • 3
  • Quan Yuan
    • 4
  1. 1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanChina
  2. 2.Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanChina
  3. 3.Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanChina
  4. 4.College of Chemistry and Molecular SciencesWuhan UniversityWuhanChina

About the editors

Fan Xia is currently a professor at Huazhong University of Science and Technology (HUST) and Dean of the Faculty of Materials Science and Chemistry, China University of Geosciences (Wuhan). He received his BSc degree (2003) from HUST and PhD degree (2008) from the Institute of Chemistry, Chinese Academy of Sciences (ICCAS) (Lei Jiang’s group). He then worked as a postdoctoral fellow in Prof. Alan J. Heeger’s group at the University of California, Santa Barbara. He joined HUST as part of the 1000 Young Talents Program in 2012. His scientific interest focuses on bio-analytical chemistry.

Xiaojin Zhang is currently a professor at China University of Geosciences (Wuhan). He received his BSc (2007) and PhD degrees (2012) from Wuhan University (Renxi Zhuo’s group). He then worked as a postdoctoral fellow in Prof. Peter X. Ma’s group at the University of Michigan, Ann Arbor. He joined China University of Geosciences (Wuhan) in 2016. His scientific interests focus on nanomaterials for theranostics.

Xiaoding Lou is currently a professor at China University of Geosciences (Wuhan). She received her PhD degree (2012) from Wuhan University (Zhen Li’s group). She then worked as a research associate in Prof. Ben Zhong Tang’s group at the Hong Kong University of Science and Technology. She joined China University of Geosciences (Wuhan) in 2017. Her scientific interests focus on the chemical and biosensor field.

Quan Yuan is currently a professor at Wuhan University. She received her BSc degree (2004) from Wuhan University and PhD degree (2009) from Peking University (Chunhua Yan’s group). She then worked as a postdoctoral fellow in Prof. Weihong Tan’s group at the University of Florida. She joined Wuhan University in 2011. Her scientific interests focus on upconversion nanoparticles and DNA nanotechnology.

Bibliographic information

Industry Sectors
Biotechnology
Chemical Manufacturing
Consumer Packaged Goods
Pharma

Reviews

“This book is fairly comprehensive in its coverage and provides useful insights into a multitude of unique research endeavors beyond biosensors and sandwich assays. These insights include an extensive discussion devoted to the relevance of analytes at varying molecular levels, fundamentals, and developments in complementary and utilitarian detection techniques, as well as materials science considerations.” (Susana Campuzano, Analytical and Bioanalytical Chemistry, Vol. 410, 2018)