© 2017

Protein Reviews

Volume 19

  • M. Zouhair Atassi

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1051)

Also part of the Protein Reviews book sub series (PROTRE, volume 1051)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Ronald Sluyter
    Pages 17-53
  3. Toshimitsu Kawate
    Pages 55-69
  4. Jolanta Barańska, Rafał Czajkowski, Paweł Pomorski
    Pages 71-89
  5. Fernand-Pierre Gendron, Morgane Placet, Guillaume Arguin
    Pages 91-106
  6. Raquel Pérez-Sen, Rosa Gómez-Villafuertes, Felipe Ortega, Javier Gualix, Esmerilda G. Delicado, María Teresa Miras-Portugal
    Pages 139-168
  7. Marta Fumagalli, Davide Lecca, Giusy T. Coppolino, Chiara Parravicini, Maria P. Abbracchio
    Pages 169-192
  8. Katia Varani, Fabrizio Vincenzi, Stefania Merighi, Stefania Gessi, Pier Andrea Borea
    Pages 193-232
  9. Sung-Hwan Cho, Cuong The Nguyen, Jeongmin Choi, Gary Stacey
    Pages 233-253
  10. Back Matter
    Pages 255-256

About this book


The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments.

Volume 19 focusses on Purinergic receptors, also termed purinoceptors. These are plasma membrane proteins present in nearly all mammalian tissues. They participate in a number of cell functions that include proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion and have been associated with learning and memory, feeding conduct, movement and sleep. They facilitate relaxation of smooth muscle of the gut in response to adenosine (P1 receptors) or ATP (P2 receptors).

The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected receptor proteins. The first chapter in this volume reviews the current research on the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1. This is followed by a chapter dealing with Structure and function of the two-component cytotoxins of Staphylococcus aureus and a chapter on Membrane Fusion and Infection involving the Influenza virus Hemagglutinin. The fourth chapter reviews the impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel. Then there is a chapter that discusses some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation. The next chapter deals with regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes. This is followed by a chapter on coding of Class I and II aminoacyl-tRNA synthetases; a chapter on regulation of nephrin phosphorylation in diabetes and chronic kidney injury and a chapter on The Structure-Forming Juncture in oxidative protein folding and the events in the ER. Finally the last chapter deals with the polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.



Protein Science Protein Structure Receptor Proteins Protein Activity Protein Function

Editors and affiliations

  • M. Zouhair Atassi
    • 1
  1. 1.Biochem and Mol BiolBaylor College of MedicineHoustonUSA

Bibliographic information

  • Book Title Protein Reviews
  • Book Subtitle Volume 19
  • Editors M. Zouhair Atassi
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-10-7610-7
  • Softcover ISBN 978-981-13-5659-9
  • eBook ISBN 978-981-10-7611-4
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VIII, 256
  • Number of Illustrations 2 b/w illustrations, 28 illustrations in colour
  • Topics Protein Structure
  • Buy this book on publisher's site
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