© 2017

DNA Replication

From Old Principles to New Discoveries

  • Hisao Masai
  • Marco Foiani
  • Presents a historical overview of eukaryotic DNA replication by one of the legendary scientists in the field

  • Reviews comprehensive compilation of the newest information on DNA replication

  • Approaches issues related to DNA replication from various points of view

  • Emphasizes the latest results on mechanistic and structural aspects of DNA replication

  • Features the most recent development on the genome-wide view of where and when DNA replication starts and stops, and how those profiles are correlated with other genomic signatures

  • Provides a novel concept for the highly adaptive and plastic mode of eukaryotic DNA replication


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Anna B. Marks, Haiqing Fu, Mirit I. Aladjem
    Pages 43-59
  3. Stephen D. Bell
    Pages 99-115
  4. Joseph L. Stodola, Peter M. Burgers
    Pages 117-133
  5. Agnieszka Gambus
    Pages 163-187
  6. Lin Bai, Zuanning Yuan, Jingchuan Sun, Roxana Georgescu, Michael E. O’Donnell, Huilin Li
    Pages 207-228
  7. Peiyao A. Zhao, Juan Carlos Rivera-Mulia, David M. Gilbert
    Pages 229-257
  8. Marie-Noëlle Prioleau
    Pages 273-286
  9. Kenji Moriyama, Mong Sing Lai, Hisao Masai
    Pages 287-310
  10. Constance Alabert, Zuzana Jasencakova, Anja Groth
    Pages 311-333
  11. Gavin D. Grant, Jeanette G. Cook
    Pages 335-369
  12. Sara Villa-Hernández, Avelino Bueno, Rodrigo Bermejo
    Pages 395-419

About this book


This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.


Replication origins DNA replication initiation factors: DnaA, ORC, MCM Replication timing: TAD, LAD, and Rif1 Chromatin regulation of DNA replication Structures of replication complexes: Cryoelectron microscopy Ubiquitination and SUMOylation of replication factors Replication/transcription collision G-quadruplex and RNA–DNA hybrids Replication fork factors Chromosomal fragile sites Clamp loaders Repetitive DNA elements Genome instability DNA polymerases FEN1

Editors and affiliations

  • Hisao Masai
    • 1
  • Marco Foiani
    • 2
  1. 1.Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan
  2. 2.Istituto FIRC di Oncologia MolecolareMilanItaly

About the editors

Hisao Masai, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Marco Foiani, IFOM,  Instituto FIRC di Oncologia Molecolare, Milan, Italy

Bibliographic information

  • Book Title DNA Replication
  • Book Subtitle From Old Principles to New Discoveries
  • Editors Hisao Masai
    Marco Foiani
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-10-6954-3
  • Softcover ISBN 978-981-13-4972-0
  • eBook ISBN 978-981-10-6955-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 581
  • Number of Illustrations 7 b/w illustrations, 87 illustrations in colour
  • Topics Cell Biology
    Biochemistry, general
  • Buy this book on publisher's site
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“This text provides impressively comprehensive coverage of the important topics and current questions in DNA replication. It will be best suited for readers with strong backgrounds in molecular biology. … Recommended. Graduate students, researchers, faculty, and professionals.” (M. S. Kainz, Choice, Vol. 56 (1), September, 2018)