© 2017

Role of Transcription Factors in Gastrointestinal Malignancies

  • Ganji Purnachandra Nagaraju
  • Pallaval Veera  Bramhachari


  • This book highlights different transcription factors that are involved in gastro-intestinal cancers

  • It describes the roles of transcription factors in tumor growth and tumor cell metastasis including migration, invasion and angiogenesis

  • This book also elucidates the rational targets for gastro-intestinal cancers therapy


Table of contents

  1. Front Matter
    Pages i-ix
  2. Pallaval Veera Bramhachari, Ganji Purnachandra Nagaraju
    Pages 1-3
  3. Himanshu Tillu, Ganji Purnachandra Nagaraju
    Pages 5-17
  4. P. S. Sushma, P. UdayKumar, Aliya Sheik
    Pages 19-32
  5. Pallaval Veera Bramhachari, A. M. V. N. Prathyusha, D. Rama Sekhara Reddy
    Pages 33-44
  6. Prudhvi Lal Bhukya, Rongala Laxmivandana, Gopinath Meenakshi Sundaram
    Pages 45-71
  7. A. M. V. N. Prathyusha, Godi Raghu, Pallaval Veera Bramhachari
    Pages 73-89
  8. Shakuntala Mahilkar, Prudhvi Lal Bhukya, L. S. Bhargavi
    Pages 91-100
  9. Neha Merchant, Ganji Lakshmi Vara Prasad, Ganji Purnachandra Nagaraju
    Pages 101-106
  10. Nageswara Rao Reddy Neelapu
    Pages 107-130
  11. Sasidhar Eda, Ramakrishna Vadde, Rajeswari Jinka
    Pages 131-159
  12. Kishore Kumar Jella
    Pages 161-177
  13. Aleem Basha Pinjari, Abdul Razak Meerza
    Pages 179-191
  14. A. M. V. N. Prathyusha, Renuka Nawadkar, Pallaval Veera Bramhachari
    Pages 193-204
  15. Tapan K. Barik, Surya N. Swain
    Pages 205-214
  16. Uday Sankar Allam, Shilpa Kamatham, Maraline Adarsha, Sk. Md. Jasmine, P. V. Giri Prasad
    Pages 215-237
  17. Siva Krishna Prasad Konduru, Ganji Lakshmi Vara Prasad, Neha Merchant, Santoshi Muppala
    Pages 239-248
  18. A. Hartley, H. Wei, L. Prabhu, M. Martin, T. Lu
    Pages 249-262
  19. Ganji Purnachandra Nagaraju, Subasini Pattnaik
    Pages 263-267
  20. Vajravathi Lakkim, Madhava C. Reddy, Durbaka V. R. Prasad, Dakshayani Lomada
    Pages 269-298

About this book


This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.


Gastrointestinal maligancies Transcription factors Signaling Pathways Tumor growth Drug targets

Editors and affiliations

  • Ganji Purnachandra Nagaraju
    • 1
  • Pallaval Veera  Bramhachari
    • 2
  1. 1.Department of Hematology and Medical OncologyEmory UniversityAtlantaUSA
  2. 2.Department of BiotechnologyKrishna UniversityMachilipatnamIndia

About the editors

Dr. Nagaraju GP is a faculty member at the Department of Hematology and Medical Oncology, Emory University School of Medicine. He completed his MS and his Ph.D., both in biotechnology, at Sri Venkateswara University, India. His research chiefly focuses on translational projects related to gastrointestinal malignancies. He has published over 60 research articles in highly reputed international journals and has presented more than 50 abstracts at various national and International conferences. He has also served as an editorial board member of several internationally recognized academic journals. He is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, the RNA Society and the American Association of Cancer Research (AACR).

Dr. Bramhachari PV is presently a member of Faculty and Head of the Department of Biotechnology at Krishna University, India. His current research work largely focuses on basic and translational cancer research. He completed his Ph.D. at Goa University, India and began his professional career as a postdoctoral scientist at the Indian Institute of Science, Bangalore, before working at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research in Brisbane, Australia. He has published more than 60 research articles in several prestigious peer-reviewed journals and presented 40 abstracts at various national and international conferences. He has successfully completed two major research projects, is a member of various prestigious scientific societies, and has served as an editorial board member and reviewer for several peer-reviewed international journals. As a leading researcher in the field of cancer biology, he is currently investigating the role of various transcriptional factors in the identification of novel cancer therapies for GI cancers.

Bibliographic information

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