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Mitochondrial DNA and Diseases

  • Hongzhi Sun
  • Xiangdong Wang

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1038)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Hongzhi Sun, Weibin Shi, Xiangdong Wang
    Pages 1-8
  3. Fangming Liu, David E. Sanin, Xiangdong Wang
    Pages 9-22
  4. Mengjia Qian, Claudio Spada, Xiangdong Wang
    Pages 23-38
  5. Lingyan Wang, Michael N. Liebmen, Xiangdong Wang
    Pages 39-53
  6. Dongli Song, Dragos Cretoiu, Xiangdong Wang
    Pages 55-70
  7. Jiapei Lv, Madhav Bhatia, Xiangdong Wang
    Pages 71-83
  8. Linlin Zhang, Aurelio Reyes, Xiangdong Wang
    Pages 85-105
  9. William Wang, Jiayuan Hou, Zhenghua Zhu, Hao Fang
    Pages 107-116
  10. Danyan Gao, Bijun Zhu, Hongzhi Sun, Xiangdong Wang
    Pages 117-132
  11. Jiayun Hou, Mohmmad Eldeeb, Xiangdong Wang
    Pages 133-148
  12. Yue Pan, Min Cao, Jianzhou Liu, Qing Yang, Xiaoyu Miao, Vay Liang W. Go et al.
    Pages 149-171
  13. Linlin Zhang, William Wang, Bijun Zhu, Xiangdong Wang
    Pages 183-200
  14. Linlin Zhang, William Wang, Bijun Zhu, Xiangdong Wang
    Pages 201-217
  15. Zhenhua Zhu, Xiangdong Wang
    Pages 219-230

About this book

Introduction

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

Keywords

mitochondrial DNA lung diseases mitochondrial DNA repair mitochondria and metabolism mitochondrial homeostasis

Editors and affiliations

  • Hongzhi Sun
    • 1
  • Xiangdong Wang
    • 2
  1. 1.Liaoning Province Key Laboratory of Cancer MetabolomicsJinzhou Hospital of Jinzhou Medical UniversityJinzhouChina
  2. 2.Zhongshan Hospital Institute of Clinical ScienceFudan University, Shanghai Medical CollegeShanghaiChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-10-6674-0
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-10-6673-3
  • Online ISBN 978-981-10-6674-0
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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