DJ-1/PARK7 Protein

Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases

  • Hiroyoshi Ariga
  • Sanae M. M. Iguchi-Ariga

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1037)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga
    Pages 1-4
  3. Nathan Smith, Mark A. Wilson
    Pages 5-24
  4. Daria Antipova, Rina Bandopadhyay
    Pages 25-43
  5. Takahiko Kawate, Benio Tsuchiya, Keiichi Iwaya
    Pages 45-59
  6. An Chunna, Xiao-Ping Pu
    Pages 61-66
  7. Prahlad V. Raninga, Giovanna Di Trapani, Kathryn F. Tonissen
    Pages 67-87
  8. Kazuko Takahashi-Niki, Takeshi Niki, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga
    Pages 89-95
  9. Stephanie E. Oh, M. Maral Mouradian
    Pages 97-131
  10. Mouadh Mihoub, Jad Abdallah, Gilbert Richarme
    Pages 133-147
  11. Yoshiro Saito
    Pages 149-171
  12. Daniel Eberhard, Eckhard Lammert
    Pages 173-186
  13. Masatoshi Inden, Daijiro Yanagisawa, Masanori Hijioka, Hiroyoshi Ariga, Yoshihisa Kitamura
    Pages 187-202
  14. Ji Cao, Xiaobing Chen, Meidan Ying, Qiaojun He, Bo Yang
    Pages 203-222

About this book


This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. 


DJ-1 Parkinson’s disease Cancer Type 2 diabetes Male infertility Oxidative stress Mitochondria Signal transduction Biomarker Therapeutic drug

Editors and affiliations

  • Hiroyoshi Ariga
    • 1
  • Sanae M. M. Iguchi-Ariga
    • 2
  1. 1.Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan
  2. 2.Faculty of AgricultureHokkaido UniversitySapporoJapan

Bibliographic information

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