Understanding Depression

Volume 1. Biomedical and Neurobiological Background

  • Yong-Ku Kim

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Genetic and Epigenetic Aspects of Depression

  3. Molecular- and Cellular-Level Aspects of Depression

    1. Front Matter
      Pages 81-81
    2. Meysam Amidfar, Lejla Colic, Martin Walter, Yong-Ku Kim
      Pages 83-95
    3. Gislaine Z. Réus, Zuleide M. Ignácio, Helena M. Abelaira, João Quevedo
      Pages 107-114
    4. Je-Yeon Yun, Seung-Hwan Lee
      Pages 115-128
  4. Neural Circuit-Level Aspect of Depression

    1. Front Matter
      Pages 129-129
    2. Kai Zhang, Jing Huang, Jin Feng, Hong Zhang, Mei Tian
      Pages 131-143
    3. Boudewijn J. H. B. de Pont, Jeroen A. Van Waarde, Guido A. van Wingen
      Pages 153-160
    4. Rafael C. R. Freire, Antonio E. Nardi
      Pages 177-187
  5. Multicellular System-Level Aspect of Depression

    1. Front Matter
      Pages 189-189
    2. Alper Evrensel, Mehmet Emin Ceylan
      Pages 197-207
    3. Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji et al.
      Pages 209-219
    4. Boldizsár Czéh, Ove Wiborg, Eberhard Fuchs
      Pages 221-231
  6. Individual-, Age-, Gender-, and Culture-Specific Aspects of Depression

    1. Front Matter
      Pages 243-243
    2. Giampaolo Perna, Raffaele Balletta, Charles B. Nemeroff
      Pages 245-261
    3. Neha Jain, David C. Steffens
      Pages 279-295
    4. Seoyoung Yoon, Yong-Ku Kim
      Pages 297-307
    5. Joao P. De Aquino, Alicia Londono, André F. Carvalho
      Pages 309-315
  7. Back Matter
    Pages 317-322

About this book


This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.


Pharmacogenetics Imaging genetics Early life stress Seretonin receptors Glutamate receptors mTOR pathway Cellular aging Biological markers Neuroimaging Cortical-subcortical interactions Novel drug discovery Personalized clinical approach Gender differences Epidemiology of major depressive disorder

Editors and affiliations

  • Yong-Ku Kim
    • 1
  1. 1.College of MedicineKorea UniversityKyonggi-doKorea (Republic of)

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-6579-8
  • Online ISBN 978-981-10-6580-4
  • Buy this book on publisher's site
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Health & Hospitals