© 2018

Developments and Applications of Calcium Phosphate Bone Cements

  • Changsheng Liu
  • Hongyan He

Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 9)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Fangping Chen, Xiaoyu Ma, Yuanman Yu, Changsheng Liu
    Pages 1-39
  3. Fangping Chen, Yuanman Yu, Xiaoyu Ma, Changsheng Liu
    Pages 147-186
  4. Jing Wang, Changsheng Liu
    Pages 187-226
  5. Hongyan He, Zhongqian Qiao, Changsheng Liu
    Pages 227-255
  6. Yifan Ma, Baolin Huang, Dan Lin, Yuan Yuan, Changsheng Liu
    Pages 257-298
  7. Shuxin Qu, Jie Weng, Ke Duan, Yumei Liu
    Pages 299-332
  8. Jun Ma, Shenglong Tan, Shengmin Zhang
    Pages 333-353
  9. Fengxuan Han, Chen Shi, Huilin Yang, Bin Li
    Pages 449-472
  10. Zhidao Xia, Yunsong Shi, Hongyan He, Yuanzhong Pan, Changsheng Liu
    Pages 517-545
  11. Lingyan Cao, Deliang Zeng, Shuxian Lin, Xiao Wang, Xiangkai Zhang, Ao Zheng et al.
    Pages 597-624

About this book


This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications. 


Calcium phosphate cements Bioactive composites Bone regeneration 3D-printing bioscaffolds Regenerative medicine

Editors and affiliations

  • Changsheng Liu
    • 1
  • Hongyan He
    • 2
  1. 1.Key Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghaiChina
  2. 2.Engineering Research Center for Biomedical Materials of Ministry of EducationEast China University of Science and TechnologyShanghaiChina

About the editors

Prof. Changsheng Liu is a Cheung Kong Scholar Professor at the School of Materials Science and Engineering of East China University of Science and Technology (ECUST). He is the director of the Ministry of Education’s Engineering Research Center for Biomedical Materials. Prof. Liu received his Ph.D. in Chemical Engineering from ECUST in 1996. He was a visiting professor at the University of Pennsylvania in 2005. His research interest focuses on the interactions between biomaterials and microenvironments and designing bioactive materials for in situ tissue regeneration. He has devoted to developing various biomaterials including CPC formulations with the superior properties and building the relationship between CPC-based biomaterials and clinic applications for over 20 years. Six CPC-based products and one bioengineered growth factor developed by Prof. Liu have been sold on the market and used in more than 500 hospitals in China. He has more than 200 refereed journal publications, 60 patents and invention disclosures, and 3 edited books to his name. His excellent innovations and significant contributions have earned him numerous honors and awards, including second prize at the National Award for Science and Technology Progress in 2003, the Ho Leung Ho Lee Foundation Scientific and Technological Innovation Award of 2007, International Fellow of Biomaterials Science and Engineering in 2012, and the second-prize of the National Award for Natural Sciences in 2014. He is also an editor for several journals, including Biomaterials Research, Biomatter, the Journal of Orthopaedic Translation, the Journal of Materiomics, and the Journal of Inorganic Materials.

Dr. Hongyan He is an associate professor at the Ministry of Education’s Engineering Research Center for Biomedical Materials at ECUST. She received her B.S. degree in Chemical Engineering at Tsinghua University in 1997, completed her Ph.D. degree in Chemical and Biomolecular Engineering at the Ohio State University (OSU), and received an OSU Presidential Fellowship in 2006. Her doctoral work focused on cutting-edge research in developing novel biomedical systems for drug delivery. Then, she served as a key research engineer at the Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymer Biomedical Devices at OSU. Before joining ECUST in 2013, she worked as a principle scientist at BioLOC LLC. in the USA, and directed the research and development of automatic ELISA microfluidic chips by combining advanced surface modification and micro/nano fabrication technologies. She has published over 30 refereed journal articles, 2 book chapters, and holds 3 patents. Currently, her research interests include nanoscale phenomena at the surface and interface of bone-repairing biomaterials and development of low-cost biochip/biosensors.

Bibliographic information

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