© 2017

Translational Research in Stroke

  • Paul A. Lapchak
  • Guo-Yuan Yang
  • Summarizes the latest developments in translational research in stroke

  • Offers new therapeutics or rehabilitation and regenerative strategies

  • Provides a basis for effective translational research


Part of the Translational Medicine Research book series (TRAMERE)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Stroke Epidemiology-Diagnosis

    1. Front Matter
      Pages 1-1
    2. Konark Malhotra, David S. Liebeskind
      Pages 29-39
    3. Chad M. Miller
      Pages 41-49
    4. Yongfang Li, Guo-Yuan Yang
      Pages 51-75
    5. Zhongsong Shi
      Pages 77-96
    6. Jin Cao, Min Lou
      Pages 97-126
    7. Noelia Rodriguez-Villatoro, David Rodriguez-Luna
      Pages 127-151
    8. Jun Huang, Pingjin Gao
      Pages 153-167
    9. Tingting He, Jieli Geng, Zhijun Zhang
      Pages 169-198
  3. Stroke Mechanisms

    1. Front Matter
      Pages 199-199
    2. Qiang Li, Shane Gao
      Pages 201-221
    3. Parisa Tabeshmehr, Seyed Mojtaba Hosseini, Aliashghar Karimi, Seyyed Mohyeddin Ziaee
      Pages 223-236
    4. Ran Xu, Adnan Ghori, Ulf C. Schneider, Peter Vajkoczy
      Pages 279-295
    5. Wanlu Li, Yongting Wang
      Pages 297-317
    6. Xuejing Zhang, Ping Sun, Ke-Jie Yin
      Pages 319-356
    7. Liping Wang, Chuan Qin, Guo-Yuan Yang
      Pages 357-379
  4. Stroke Therapy

    1. Front Matter
      Pages 381-381

About this book


This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. 
Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology. 


Stroke Translational research Neurogenesis Gene therapy Stroke rehabilitation

Editors and affiliations

  • Paul A. Lapchak
    • 1
  • Guo-Yuan Yang
    • 2
  1. 1.Department of Neurology & NeurosurgeryCedars-Sinai Medical Center, Advanced Health Sciences PavilionLos AngelesUSA
  2. 2.Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityChina

About the editors

Dr. Paul A. Lapchak is Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA; 
Dr. Guoyuan Yang is Professor at the School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Bibliographic information

  • Book Title Translational Research in Stroke
  • Editors Paul A. Lapchak
    Guo-Yuan Yang
  • Series Title Translational Medicine Research
  • Series Abbreviated Title Translational Medicine Research
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd.and Shanghai Jiao Tong University Press 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-10-5803-5
  • Softcover ISBN 978-981-13-5495-3
  • eBook ISBN 978-981-10-5804-2
  • Series ISSN 2451-991X
  • Series E-ISSN 2451-9928
  • Edition Number 1
  • Number of Pages VII, 581
  • Number of Illustrations 34 b/w illustrations, 31 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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“This is a collection of research topics about various aspects of stroke, including an in-depth comparison of the trials that led to current practices, a breakdown of the pathophysiology of mechanisms involved in stroke, imaging, and future advances. … This is an excellent combination of academic principles and discussions of the relevant research studies. This book is ideal for an audience interested in neurology on both research and academic levels.” (Alison Caruana, Doody's Book Reviews, April, 2018)