© 2018

Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

  • Takeo Kubota
  • Hideoki Fukuoka

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1012)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Biological Basis

    1. Front Matter
      Pages 1-1
    2. Hideoki Fukuoka, Takeo Kubota
      Pages 3-9
    3. Kazuki Mochizuki, Natsuyo Hariya, Takeo Kubota
      Pages 11-18
    4. Koshi Hashimoto, Yoshihiro Ogawa
      Pages 19-25
  3. Disease and Environment

    1. Front Matter
      Pages 27-27
    2. Hiroaki Itoh, Naohiro Kanayama
      Pages 29-39
    3. Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita
      Pages 41-48
  4. Transgenerational Mechanism and Its Consequences

    1. Front Matter
      Pages 61-61
    2. Kosuke Taniguchi, Tomoko Kawai, Kenichiro Hata
      Pages 63-73
  5. Clinical Significance

    1. Front Matter
      Pages 83-83

About this book


This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.


Epigenome Pre-emptive medicine Metabolic disease Maternal under-nutrition Nutritional environment

Editors and affiliations

  • Takeo Kubota
    • 1
  • Hideoki Fukuoka
    • 2
  1. 1.Faculty of Child StudiesSeitoku UniversityMatsudoJapan
  2. 2.Research Organization for Nano & Life InnovationWaseda UniversityTokyoJapan

About the editors

Takeo Kubota

Faculty of Child Studies, Seitoku University, Chiba, Japan

Hideoki Fukuoka

Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Bibliographic information

  • Book Title Developmental Origins of Health and Disease (DOHaD)
  • Book Subtitle From Biological Basis to Clinical Significance
  • Editors Takeo Kubota
    Hideoki Fukuoka
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-981-10-5525-6
  • Softcover ISBN 978-981-13-3856-4
  • eBook ISBN 978-981-10-5526-3
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VII, 95
  • Number of Illustrations 7 b/w illustrations, 16 illustrations in colour
  • Topics Human Physiology
    Reproductive Medicine
    Developmental Biology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals