Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

  • Andrew A. Udy
  • Jason A. Roberts
  • Jeffrey Lipman

Table of contents

  1. Front Matter
    Pages i-x
  2. Kashyap Patel, Carl M. Kirkpatrick
    Pages 1-16
  3. Fekade B. Sime, Jason A. Roberts
    Pages 17-29
  4. Maya Hites, Fabio Silvio Taccone
    Pages 47-72
  5. Gordon Y. S. Choi, Gavin M. Joynt
    Pages 101-124
  6. João Pedro Baptista
    Pages 125-150
  7. Mohd. H. Abdul-Aziz, Kiran Shekar, Jason A. Roberts
    Pages 151-171
  8. Jana Stojanova, Sonia Luque
    Pages 173-199
  9. Roger J. M. Brüggemann, Dylan W. de Lange, Jan-Willem C. Alffenaar
    Pages 213-238
  10. Pieter A. J. G. De Cock, Karel Allegaert, Matthew W. Linakis, Catherine M. T. Sherwin
    Pages 239-263
  11. M. Gilchrist, E. T. Brannigan, G. Satta, M. Laundy
    Pages 265-275

About this book


This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics.

Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU.  Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.


Infectious diseases Dosing Therapeutic drug monitoring TDM Antibiotic stewardship Bacterial susceptibility Physiological manifestations Hypoalbuminaemia Renal disease Obese patients Extracorporeal membrane oxygenation Critical care

Editors and affiliations

  • Andrew A. Udy
    • 1
  • Jason A. Roberts
    • 2
  • Jeffrey Lipman
    • 3
  1. 1.Australian and New Zealand Intensive Care Research CentreSchool of Public Health and Preventive Medicine, Monash UniversityMelbourneAustralia
  2. 2.Burns, Trauma and Critical Care Research CentreThe University of QueenslandHerstonAustralia
  3. 3.Burns, Trauma and Critical Care Research CentreThe University of QueenslandHerstonAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Adis, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-5335-1
  • Online ISBN 978-981-10-5336-8
  • Buy this book on publisher's site
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