© 2019

Treatment Resistance in Psychiatry

Risk Factors, Biology, and Management

  • Yong-Ku Kim

Table of contents

  1. Front Matter
    Pages i-xv
  2. Rethinking the Treatment Resistance in Psychiatry

    1. Front Matter
      Pages 1-1
    2. Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Robert A. Schoevers
      Pages 3-24
    3. Sang Won Jeon, Meysam Amidfar, Yong-Ku Kim
      Pages 25-31
    4. Eduard Maron, Chen-Chia Lan, David Nutt
      Pages 33-63
  3. Treatment Resistance in Specific Disorders

    1. Front Matter
      Pages 97-97
    2. Sandeep Grover, Harsh Garekar, Anisha Agarwal
      Pages 109-137
    3. Marsal Sanches, João Quevedo, Jair C. Soares
      Pages 139-150
    4. Alexander Cowell McFarlane
      Pages 151-164
    5. Rachel Middleton, Michael G. Wheaton, Reilly Kayser, H. Blair Simpson
      Pages 165-177
    6. Michael Soyka
      Pages 179-187
    7. Mu-Hong Chen, Shih-Jen Tsai
      Pages 189-206
    8. Amber D. Hunt, David W. Dunn, Hillary S. Blake, Jennifer Downs
      Pages 215-235
    9. Renata Rizzo, Mariangela Gulisano
      Pages 237-252
    10. Youl-Ri Kim, Jione Kim
      Pages 253-260

About this book


This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.


psychiatric disorders treatment resistance therapeutic interventions psychiatry risk factors predictors

Editors and affiliations

  • Yong-Ku Kim
    • 1
  1. 1.Department of Psychiatry, College of MedicineKorea UniversitySeoulKorea (Republic of)

About the editors

Yong-Ku Kim, MD, PhD
Department of Psychiatry, Korea University Ansan Hospital, South Korea 

Bibliographic information

  • Book Title Treatment Resistance in Psychiatry
  • Book Subtitle Risk Factors, Biology, and Management
  • Editors Yong-Ku Kim
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-10-4357-4
  • eBook ISBN 978-981-10-4358-1
  • Edition Number 1
  • Number of Pages XV, 416
  • Number of Illustrations 28 b/w illustrations, 10 illustrations in colour
  • Topics Psychiatry
  • Buy this book on publisher's site
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