© 2017

RNA Activation

  • Long-Cheng Li


  • Provides a comprehensive knowledge of RNA activation

  • Chapters highlight recent advances in specific topics

  • Refers to several kinds of cancer

  • Contributed by world recognized experts in this field


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 983)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Exogenous RNAa

  3. Endogenous RNAa

    1. Front Matter
      Pages 63-63
    2. Ramani Ramchandran, Pradeep Chaluvally-Raghavan
      Pages 81-89
    3. Yijun Zhang, Hui Zhang
      Pages 91-111
    4. Qingping Zou, Ying Liang, Huaibing Luo, Wenqiang Yu
      Pages 113-125
  4. RNA Activation Guided by Other Small RNAs

    1. Front Matter
      Pages 127-127
    2. Meng Chen, Lei Stanley Qi
      Pages 147-157
  5. Developing RNAa-Based Therapeutics

    1. Front Matter
      Pages 159-159
    2. Xiaoyang Zhao, Jon Voutila, Stephanos Ghobrial, Nagy A. Habib, Vikash Reebye
      Pages 189-194
    3. Tiia A. Turunen, Seppo Ylä-Herttuala, Mikko P. Turunen
      Pages 195-205

About this book


This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).

With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development. 


RNA Activation/ RNAa RNA interference RNA sequencing Genome editing small RNA epigenetics

Editors and affiliations

  • Long-Cheng Li
    • 1
  1. 1.Laboratory of Molecular MedicinePeking Union Medical College Hospital, Chinese Academy of Medical SciencesBeijingChina

About the editors

Dr. Long-Cheng Li is a professor at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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