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Regenerative Medicine: Laboratory to Clinic

  • Asok Mukhopadhyay

Table of contents

  1. Front Matter
    Pages i-xix
  2. Disease Biology and Basic Stem Cells

  3. Potential Clinical Studies

    1. Front Matter
      Pages 159-159
    2. Bhawna Chandravanshi, Ramesh Ramchandra Bhonde
      Pages 161-172
    3. Anupam Kumar
      Pages 173-194
    4. Shubha Tiwari, Geeta K. Vemuganti
      Pages 195-207
    5. Neel Kamal Sharma, Deepali Mathur, Monika Vinish, Rupali Sharma, Kulsajan Bhatia, Viraaj Pannu et al.
      Pages 209-231
    6. Aditya Arora, Arijit Bhattacharjee, Aman Mahajan, Dhirendra S. Katti
      Pages 233-257
    7. Swati Midha, Sourabh Ghosh
      Pages 259-276
    8. Niranjan Bhattacharya
      Pages 277-284
    9. Geeta Jotwani, Gitika Kharkwal
      Pages 285-297
  4. Bed Side Applications

    1. Front Matter
      Pages 341-341
    2. Sachin Shukla, Vivek Singh, Indumathi Mariappan, Virender S. Sangwan
      Pages 381-407
    3. Hargovind L. Trivedi, Aruna V. Vanikar
      Pages 409-421
    4. Manoj Komath, H. K. Varma, Annie John, Vinod Krishnan, Deepti Simon, Manikandhan Ramanathan et al.
      Pages 423-447
    5. Vrisha Madhuri, Karthikeyan Rajagopal, Sowmya Ramesh
      Pages 471-494
    6. Sudha Balasubramanian, Mathiyazhagan Rengasamy, Charan Thej, Pawan K. Gupta, Anish S. Majumdar
      Pages 495-510
  5. Back Matter
    Pages 531-537

About this book

Introduction

This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering. It examines in detail the therapeutic application of hematopoietic stem cells in marrow regeneration, multi-potent mesenchymal stem cells (MSCs), also referred to as mesenchymal stromal cells. The interest in MSCs can be seen in more than 150 clinical trials, some of which have progressed to Phase III, despite the cells’ limited differentiation potential. The book also explores how embryonic stem (ES) cells, being pluripotent in nature, can resolve some of the problems associated with adult stem cells, yet entail other challenges like risks of teratoma formation and immune rejection. A separate chapter deals with the role of noncoding RNAs in neuronal commitment of induced pluripotent stem (iPS) cells.

Chapters like “Cord blood banking in India and the global scenario”; “3D bioprinting of tissue” and others will make this book an extremely interesting read for all students, researchers and clinicians working in the area of regenerative medicine/stem cells.

The book is broadly divided into three parts,  the first of which is devoted to basic information on stem cells and some aspect of disease biology, the second which addresses upcoming prospects in the regeneration of pancreas, liver, Lacrimal gland, and tissue engineering in general. Also, the second part discusses two important areas of translational regenerative medicine: challenges in pre-clinical study and manufacturing of cell based products. The third part  covers bed side applications in the areas of orthopedic, eyes, hematology, dental tissue engineering, organ transplantation, control of aging, etc. 

Keywords

Organ regeneration stem cells tissue engineering clinical translation Regenerative medicine

Editors and affiliations

  • Asok Mukhopadhyay
    • 1
  1. 1.Stem Cell Biology LaboratoryNational Institute of ImmunologyNew DelhiIndia

Bibliographic information

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