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RUNX Proteins in Development and Cancer

  • Yoram Groner
  • Yoshiaki Ito
  • Paul Liu
  • James C. Neil
  • Nancy A. Speck
  • Andre van Wijnen

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 962)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Evolution of RUNX Genes

    1. Front Matter
      Pages 1-1
    2. S. Hughes, A. Woollard
      Pages 3-18
  3. RUNX and CBFβ: Structure and Function

    1. Front Matter
      Pages 19-19
    2. Tahir H. Tahirov, John Bushweller
      Pages 21-31
    3. Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, Stephen D. Nimer
      Pages 33-44
  4. RUNX Genes and Mammalian Development

    1. Front Matter
      Pages 45-45
    2. Amanda D. Yzaguirre, Marella F. T. R. de Bruijn, Nancy A. Speck
      Pages 47-64
    3. Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud
      Pages 65-81
    4. Toshihisa Komori
      Pages 83-93
    5. Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, Gary S. Stein
      Pages 95-102
    6. Jae Woong Wang, Stefano Stifani
      Pages 103-116
    7. Chelsia Qiuxia Wang, Michelle Meng Huang Mok, Tomomasa Yokomizo, Vinay Tergaonkar, Motomi Osato
      Pages 117-138
    8. Wei-Siang Liau, Phuong Cao Thi Ngoc, Takaomi Sanda
      Pages 139-147
  5. RUNX1 and CBFβ Fusion Proteins in Leukemia

    1. Front Matter
      Pages 149-149
    2. Shan Lin, James C. Mulloy, Susumu Goyama
      Pages 151-173
    3. Aishwarya Sundaresh, Owen Williams
      Pages 201-216
    4. Anthony M. Ford, Mel Greaves
      Pages 217-228
    5. Lucio H. Castilla, John H. Bushweller
      Pages 229-244
  6. RUNX and CBFβ in Cancer and Immune Function

    1. Front Matter
      Pages 245-245
    2. James C. Neil, Kathryn Gilroy, Gillian Borland, Jodie Hay, Anne Terry, Anna Kilbey
      Pages 247-264
    3. R. Katherine Hyde, Paul Liu, Alan D. Friedman
      Pages 265-282
    4. Michelle J. West, Paul J. Farrell
      Pages 283-298
    5. Linda Shyue Huey Chuang, Kosei Ito, Yoshiaki Ito
      Pages 299-320
    6. Jung-Won Lee, Andre van Wijnen, Suk-Chul Bae
      Pages 321-332
    7. Martin C. Whittle, Sunil R. Hingorani
      Pages 333-352
    8. Nicholas Rooney, Alessandra I. Riggio, Daniel Mendoza-Villanueva, Paul Shore, Ewan R. Cameron, Karen Blyth
      Pages 353-368
    9. Joseph Lotem, Ditsa Levanon, Varda Negreanu, Omri Bauer, Shay Hantisteanu, Joseph Dicken et al.
      Pages 369-393
    10. Takashi Ebihara, Wooseok Seo, Ichiro Taniuchi
      Pages 395-413
    11. Dong Young Kim, John D. Gross
      Pages 415-431
  7. Emerging Roles for RUNX

    1. Front Matter
      Pages 433-433
    2. Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol, Megan Finch-Edmondson
      Pages 435-448
    3. Sun Hee Lee, Sarala Manandhar, You Mie Lee
      Pages 449-469
    4. Dominic Chih-Cheng Voon, Jean Paul Thiery
      Pages 471-489
  8. Back Matter
    Pages 511-515

About this book

Introduction

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.

The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. 

At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.

This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Keywords

CBFb DNA damage response RUNX epigenetic memory lineage-specific developmental regulators

Editors and affiliations

  • Yoram Groner
    • 1
  • Yoshiaki Ito
    • 2
  • Paul Liu
    • 3
  • James C. Neil
    • 4
  • Nancy A. Speck
    • 5
  • Andre van Wijnen
    • 6
  1. 1.Department of Molecular GeneticsWeizmann Institute of ScienceRehovotIsrael
  2. 2.Cancer Science Institute of SingaporeNational University of SingaporeSingaporeSingapore
  3. 3.Genetics and Molecular Biology BranchNational Human Genome Research InstituteBethesdaUSA
  4. 4.Institute of Infection, Immunity and InflammationUniversity of GlasgowGlasgowUnited Kingdom
  5. 5.Department of Cell and Development BiologyUniversity of PennsylvaniaPhiladelphiaUSA
  6. 6.Mayo ClinicRochesterUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-10-3233-2
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-10-3231-8
  • Online ISBN 978-981-10-3233-2
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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