Overview
- Nominated by Chinese Academy of Sciences as an outstanding PhD thesis
- Provides new methodologies of N-heterocyclic carbene catalysis
- Describes in detail the annulation reactions of nitroalkenes, enals and a,ß-unsaturated carboxylic acids
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (5 chapters)
Keywords
About this book
This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α,β-unsaturated carboxylic acids were first successfully employed to generate the α,β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
Authors and Affiliations
Bibliographic Information
Book Title: New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations
Authors: Xiangyu Chen
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-10-2899-1
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-2898-4Published: 30 December 2016
Softcover ISBN: 978-981-10-9734-8Published: 07 July 2018
eBook ISBN: 978-981-10-2899-1Published: 20 December 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIV, 123
Number of Illustrations: 53 b/w illustrations, 13 illustrations in colour
Topics: Organic Chemistry, Catalysis, Medicinal Chemistry
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Pharma