© 2017

Proteases in Physiology and Pathology

  • Sajal Chakraborti
  • Naranjan S. Dhalla

Table of contents

  1. Front Matter
    Pages i-xv
  2. Regulation of Proteases in Health and Disease

    1. Front Matter
      Pages 1-1
    2. Clea Bárcena, Pablo Mayoral, Pedro M. Quirós, Carlos López-Otín
      Pages 3-25
    3. Rotem Kalev-Altman, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld
      Pages 27-48
    4. Sibani Chakraborty, Ankur Chaudhuri, Asim K. Bera
      Pages 77-88
    5. Sujeet Kumar, Umashankar Das, Jonathan R. Dimmock, Rajendra K. Sharma
      Pages 89-99
    6. Abhishek Roy, Ramesh Prasad, Anindita Bhattacharya, Kaushik Das, Prosenjit Sen
      Pages 101-119
    7. Pavel Montes de Oca Balderas
      Pages 121-142
    8. Anupama Ghosh, Sanghamitra Raha
      Pages 143-158
    9. V. S. Gurupriya, Sudhir C. Roy
      Pages 195-216
    10. Mansi Manchanda, Nishat Fatima, Shyam Singh Chauhan
      Pages 217-256
    11. Nitesh Kumar Poddar, Sanjeev Kumar Maurya, Vanshika Saxena
      Pages 257-287
    12. P. V. Ravindra, T. K. Girish
      Pages 289-296
    13. Amog P. Urs, V. N. Manjuprasanna, G. V. Rudresha, M. Yariswamy, B. S. Vishwanath
      Pages 297-323
    14. Julia M. Fraile, Carlos López-Otín, José M. P. Freije
      Pages 355-382
  3. General Aspects of Proteases

    1. Front Matter
      Pages 383-383
    2. Pulak Kar, Krishna Samanta, Tapati Chakraborti, Md Nur Alam, Sajal Chakraborti
      Pages 385-395
    3. Fabiana A. Andrade, Kárita C. F. Lidani, Sandra J. Catarino, Iara J. Messias-Reason
      Pages 397-420
    4. Subrata Ganguli, C. Ratna Prabha
      Pages 421-434
    5. Shounak Jagdale, Sneha Bansode, Rakesh Joshi
      Pages 451-473
    6. K. N. Suvilesh, A. N. Nanjaraj Urs, M. N. Savitha, M. D. Milan Gowda, B. S. Vishwanath
      Pages 485-515
    7. Ratnakar Chitte, Sushma Chaphalkar
      Pages 517-526
    8. Sanchari Bhattacharjee, Rakhi Dasgupta, Angshuman Bagchi
      Pages 527-548
    9. Prranshu Yadav, Ankita Doshi, Yong Joon Yoo, C. Ratna Prabha
      Pages 549-577
    10. Amritlal Mandal, Atanu Maiti, Tapati Chakraborti, Sajal Chakraborti
      Pages 607-619

About this book


Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development.

This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.


Protease and Antiproteases Neuronal Diseases Cancer Cardiovascular Diseases Parasitic Diseases Gene Therapy

Editors and affiliations

  • Sajal Chakraborti
    • 1
  • Naranjan S. Dhalla
    • 2
  1. 1.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia
  2. 2.St. Boniface Hospital Research Centre, University of Manitoba, Faculty of Health Sciences, College of MedicineInstitute of Cardiovascular SciencesManitoba, WinnipegCanada

About the editors

Dr. Sajal Chakraborti is a senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant and calcium signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 40 years.

Dr. Naranjan S Dhalla is a distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 45 years.

Bibliographic information

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