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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

Book

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.

Keywords

Metal complex Inorganic medicine N-heterocyclic carbene Cell imaging Platinum-based anti-cancer agents Gold-based anti-cancer agents

Authors and affiliations

  1. 1.Department of ChemistryThe University of Hong KongHong KongHong Kong

About the authors

Bibliographic information

  • Book Title Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)
  • Book Subtitle Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents
  • Authors Taotao Zou
  • Series Title Springer Theses
  • Series Abbreviated Title Springer Theses
  • DOI https://doi.org/10.1007/978-981-10-0657-9
  • Copyright Information Springer Science+Business Media Singapore 2016
  • Publisher Name Springer, Singapore
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-981-10-0656-2
  • Softcover ISBN 978-981-10-9221-3
  • eBook ISBN 978-981-10-0657-9
  • Series ISSN 2190-5053
  • Series E-ISSN 2190-5061
  • Edition Number 1
  • Number of Pages XIII, 164
  • Number of Illustrations 100 b/w illustrations, 79 illustrations in colour
  • Topics Inorganic Chemistry
    Medicinal Chemistry
    Molecular Medicine
    Cancer Research
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