Squamous cell Carcinoma

Molecular Therapeutic Targets

  • Saman Warnakulasuriya
  • Zakir Khan

Table of contents

  1. Front Matter
    Pages i-xii
  2. Mahvash Tavassoli, Yae-eun Suh
    Pages 59-95
  3. Luis Monteiro, Saman Warnakulasuriya
    Pages 97-111
  4. Ramez Philips, Quintin Pan
    Pages 113-134
  5. Panomwat Amornphimoltham, Samuel J. Roth, Trey Ideker, J. Silvio Gutkind
    Pages 163-181
  6. Daniel W. Lambert, Hataitip Tasena, Paul M. Speight
    Pages 205-215
  7. Toru Nagao, Saman Warnakulasuriya
    Pages 217-278
  8. Back Matter
    Pages 279-281

About this book


This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.

The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.

Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.

This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.


Squamous-cell carcinoma Molecular carcinogenesis Molecular therapeutics and diagnostics Apoptotic targets Cell cycle regulators

Editors and affiliations

  • Saman Warnakulasuriya
    • 1
  • Zakir Khan
    • 2
  1. 1.Oral MedicineKing's College London Oral MedicineSurreyUnited Kingdom
  2. 2.Cedars-Sinai Medical CenterDepartment of Biomedical Sciences Cedars-Sinai Medical CenterLos AngelesUSA

Bibliographic information

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Health & Hospitals
Oncology & Hematology
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