© 2017


  • Baoxue Yang


  • Provides a state-of-the-art on recent developments and future directions in aquaporin research

  • Provides a systematic and comprehensive overview into aquaporins

  • Covers diverse aspects of aquaporin research

  • Written by experts in this field


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 969)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Chunling Li, Weidong Wang
    Pages 1-34
  3. Kenichi Ishibashi, Yoshiyuki Morishita, Yasuko Tanaka
    Pages 35-50
  4. Xiaoqiang Geng, Baoxue Yang
    Pages 51-62
  5. Christine Delporte
    Pages 63-79
  6. Mengmeng Xu, Ming Xiao, Shao Li, Baoxue Yang
    Pages 81-103
  7. Lu Tie, Di Wang, Yundi Shi, Xuejun Li
    Pages 105-113
  8. Yuanlin Song, Linlin Wang, Jian Wang, Chunxue Bai
    Pages 115-122
  9. Shuai Zhu, Jianhua Ran, Baoxue Yang, Zhechuan Mei
    Pages 123-130
  10. Yingjie Li, Weiling Wang, Tao Jiang, Baoxue Yang
    Pages 131-148
  11. Joan Cerdà, François Chauvigné, Roderick Nigel Finn
    Pages 149-171
  12. Ravi Patel, L. Kevin Heard, Xunsheng Chen, Wendy B. Bollag
    Pages 173-191
  13. Thuy Linh Tran, Steffen Hamann, Steffen Heegaard
    Pages 193-198
  14. Nora Martínez, Alicia E. Damiano
    Pages 199-212
  15. H. A. Jenny Lu
    Pages 213-225
  16. Inês Vieira da Silva, Graça Soveral
    Pages 227-238
  17. Lukmanee Tradtrantip, Bjung-Ju Jin, Xiaoming Yao, Marc O. Anderson, Alan S. Verkman
    Pages 239-250
  18. Boyue Huang, Hongkai Wang, Baoxue Yang
    Pages 251-261
  19. Evgeniy I. Solenov, Galina S. Baturina, Liubov E. Katkova, Sotirios G. Zarogiannis
    Pages 263-276
  20. Back Matter
    Pages 277-278

About this book


This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions.


Aquaporin Membrane transporter Transporter protein Water channel Water transport

Editors and affiliations

  • Baoxue Yang
    • 1
  1. 1.Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina

About the editors

Baoxue Yang is a professor and vice chairman of Department of Pharmacology at Peking University. He is also an adjunct professor at Jilin University and a visiting professor at Northeast Normal University. Prof. Yang has been studying urea transporter and aquaporins for nearly 20 years and published more than 70 original research articles in this field.

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