© 2016


  • Riekelt H. Houtkooper

Part of the Proteins and Cell Regulation book series (PROR, volume 10)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Yue Yang, Anthony A. Sauve
    Pages 1-27
  3. Olga Pougovkina, Vincent C. J. de Boer
    Pages 41-69
  4. Marie Boutant, Carles Cantó
    Pages 71-104
  5. Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell et al.
    Pages 105-138
  6. Bin He, Hening Lin
    Pages 139-147
  7. Bernadette M. M. Zwaans, William Giblin, David B. Lombard
    Pages 149-170
  8. Jaewon J. Lee, Karina N. Gonzalez Herrera, Marcia C. Haigis
    Pages 171-190
  9. Keir Menzies, Julien Francisco Zaldivar-Jolissaint, Johan Auwerx
    Pages 191-211
  10. Carles Cantó, Riekelt H. Houtkooper
    Pages 213-227
  11. Selma Masri, Marina Maria Bellet, Paolo Sassone-Corsi
    Pages 229-242
  12. Hassina Massudi, Lindsay E. Wu, David A. Sinclair
    Pages 243-266
  13. Brian K. Kennedy
    Pages 267-273
  14. Back Matter
    Pages 275-288

About this book


The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.


Sirtuin Aging Metabolic Disease Nicotinamide Adenine Dinucleotide Physiology

Editors and affiliations

  • Riekelt H. Houtkooper
    • 1
  1. 1.Laboratory Genetic Metabolic DiseasesAcademic Medical CenterAmsterdamThe Netherlands

Bibliographic information

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