© 2016

Regulation of Cytokine Gene Expression in Immunity and Diseases

  • Xiaojing Ma
  • Provides cutting-edge research developments on the regulation of cytokine expression

  • Illustrates the regulation of cytokine expression in both healthy physiological conditions and in pathological situations

  • Covers all major cytokines with respect to the regulation of their gene expression and protein production

  • Written by experts in this field


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 941)

Table of contents

  1. Front Matter
    Pages i-viii
  2. John Fenimore, Howard A. Young
    Pages 1-19
  3. Amir S. Yazdi, Kamran Ghoreschi
    Pages 21-29
  4. I-Cheng Ho, Shi-Chuen Miaw
    Pages 31-77
  5. Toshio Tanaka, Masashi Narazaki, Kazuya Masuda, Tadamitsu Kishimoto
    Pages 79-88
  6. Sascha Rutz, Wenjun Ouyang
    Pages 89-116
  7. Hua Zheng, Yi Ban, Fang Wei, Xiaojing Ma
    Pages 117-138
  8. Wenjuan Dong, Xiaojing Ma
    Pages 139-166
  9. Iain Welsby, Stanislas Goriely
    Pages 167-189
  10. Qinghong Wang, Jianguo Liu
    Pages 191-211

About this book


This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.



Autoimmunity Cytokine Gene expression Immunity Infection Epigenetic regulation

Editors and affiliations

  • Xiaojing Ma
    • 1
  1. 1.State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and BiotechnologyShanghai Jiaotong UniversityShanghaiChina

About the editors

Dr. Xiaojing Ma is a professor from Department of Microbiology and Immunology, Weill Cornell Medical College, USA. He is also the chair professor and associate dean of School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. He serves as the associate editor of The Journal of Immunology, and is in the editorial board of several international journals, such as The Journal of Experimental Medicine, Annual Review of Biomedical Science and Cellular and Molecular Immunology. His research focuses on molecular regulation of cytokine gene expression and their immunological activities in inflammatory diseases, and he has published more than 80 research articles on top journals in this field.

Bibliographic information

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