© 2015

Urine Proteomics in Kidney Disease Biomarker Discovery

  • Youhe Gao
  • Detailed summarizes of urine sample preparation for proteomics analysis

  • Covers a wide range of proteomics technologies

  • Describes the urine proteome change under various physiological conditions


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 845)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Urine as Biomarker Source

  3. Urine Collection, Storage and Analysis

    1. Front Matter
      Pages 21-21
    2. Liu Liu, Lulu Jia, Xuejiao Liu
      Pages 23-30
    3. Alyssa R. Huebner, Poorichaya Somparn, Thitima Benjachat, Asada Leelahavanichkul, Yingyos Avihingsanon, Robert A. Fenton et al.
      Pages 43-58
  4. Factors That Changes Urinary Proteome

    1. Front Matter
      Pages 89-89
    2. Yong Chen
      Pages 91-94
    3. Annalisa Castagna, Sarath Kiran Channavajjhala, Francesca Pizzolo, Oliviero Olivieri
      Pages 103-120
    4. Maxie Kohler, Wilhelm Schänzer, Mario Thevis
      Pages 121-131
  5. Discovery of Kidney Disease Biomarkers

    1. Front Matter
      Pages 143-143

About this book


This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair". 


kidney disease urine analysis urine and kidney biomarker urine collection urine exosome urine proteomics

Editors and affiliations

  • Youhe Gao
    • 1
  1. 1.PathophysiologyPeking Union Medical College & Inst. Basic Medical Sciences Chinese Academy of Medical SciencesBeijingChina

About the editors

Youhe Gao is a professor from Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. He is the member of the standing committee of the proteomics branch of the Chinese Society of Biochemistry and Molecular Biology. He was awarded the National Science Fund for Distinguished Young Scientists in 2007. His research is focused on human urine proteomics and its application, cell secretome and biological predication of protein-protein interaction.

Bibliographic information

  • Book Title Urine Proteomics in Kidney Disease Biomarker Discovery
  • Editors Youhe Gao
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2015
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-94-017-9522-7
  • Softcover ISBN 978-94-024-0724-2
  • eBook ISBN 978-94-017-9523-4
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 203
  • Number of Illustrations 15 b/w illustrations, 10 illustrations in colour
  • Topics Proteomics
    Molecular Medicine
  • Buy this book on publisher's site
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