Advertisement

I Domain Integrins

  • Donald Gullberg

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 819)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Mark S. Johnson, Bhanupratap Singh Chouhan
    Pages 1-19
  3. Humphrey Gardner
    Pages 21-39
  4. Aasakiran Madamanchi, Samuel A. Santoro, Mary M. Zutter
    Pages 41-60
  5. Evy Lundgren-Åkerlund, Attila Aszòdi
    Pages 61-71
  6. Cédric Zeltz, Ning Lu, Donald Gullberg
    Pages 73-83
  7. Carl G. Gahmberg, Mikaela Grönholm, Liisa M. Uotila
    Pages 85-96
  8. Robert C. Liddington
    Pages 111-126
  9. Samir Hamaia, Richard W. Farndale
    Pages 127-142
  10. Marian Brennan, Dermot Cox
    Pages 157-178
  11. Back Matter
    Pages 179-179

About this book

Introduction

The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.

I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.

Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.

In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.

New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.

Keywords

Collagen I domain Inflammation Integrin Leukocytes

Editors and affiliations

  • Donald Gullberg
    • 1
  1. 1.University of BergenBergenNorway

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-9153-3
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-9152-6
  • Online ISBN 978-94-017-9153-3
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods